Source:http://linkedlifedata.com/resource/pubmed/id/11745924
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2001-12-17
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pubmed:abstractText |
To analyze the clinical relevance of AZT resistance mutations in AZT-naive patients, 56 HIV-1 seropositive patients treated for 18 months with stavudine/lamivudine (27 patients) or AZT/lamivudine (29 patients) were studied. AZT-like resistance mutations were found in 13 out of 29 (44%) patients treated with AZT/lamivudine and in 11 out of 27 (40%) patients treated with stavudine/lamivudine. No stavudine or multi-drug resistance mutations were detected. After 26 months of treatment more than 60% of patients showed a virological failure. Among 10 patients failing treatment with stavudine/lamivudine, 9 had AZT-like resistance mutations. The phenotypic test, performed on HIV-1 strains isolated from six of these nine patients, showed a resistance to AZT in five isolates and to stavudine in two isolates. The genotypic pattern of the latter two isolates showed the combined mutations M184V plus R211K and L214F. AZT-like resistance mutations in AZT-naive patients seem to correlate with a virological failure during long-term stavudine therapy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0146-6615
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pubmed:author |
pubmed-author:AbbadessaVV,
pubmed-author:AndreoniMM,
pubmed-author:D'EttorreGG,
pubmed-author:DalleN ENE,
pubmed-author:GalliSS,
pubmed-author:MancinoGG,
pubmed-author:NarcisoPP,
pubmed-author:NicastriEE,
pubmed-author:ParishS FSF,
pubmed-author:SarmatiLL,
pubmed-author:TrainaCC,
pubmed-author:VulloVV
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pubmed:copyrightInfo |
Copyright 2001 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
631-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11745924-Anti-HIV Agents,
pubmed-meshheading:11745924-Cohort Studies,
pubmed-meshheading:11745924-Drug Resistance, Viral,
pubmed-meshheading:11745924-Drug Therapy, Combination,
pubmed-meshheading:11745924-Genotype,
pubmed-meshheading:11745924-HIV Infections,
pubmed-meshheading:11745924-HIV Seropositivity,
pubmed-meshheading:11745924-HIV-1,
pubmed-meshheading:11745924-Humans,
pubmed-meshheading:11745924-Lamivudine,
pubmed-meshheading:11745924-Mutation,
pubmed-meshheading:11745924-Stavudine,
pubmed-meshheading:11745924-Treatment Failure,
pubmed-meshheading:11745924-Zidovudine
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pubmed:year |
2001
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pubmed:articleTitle |
Failure of stavudine-lamivudine combination therapy in antiretroviral-naive patients with AZT-like HIV-1 resistance mutations.
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pubmed:affiliation |
Department of Public Health, University of Rome Tor Vergata, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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