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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-12-17
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pubmed:abstractText |
The Ku protein is a tightly associated heterodimer, comprised of 70-kilodalton (kD) and 86-kD subunits, that forms the DNA-dependent protein kinase (DNA-PK) complex together with the 470-kD DNA-PKcs catalytic subunit, and is involved mainly in DNA double-strand breaks (DSBs) repair. The objective of the current study was to investigate the expression and DNA-binding activity of the Ku protein in fresh tissues from patients with bladder carcinoma and to compare it with that in nontumor tissues obtained from the same organ. Moreover, the DNA-binding activity of Ku was assessed after exposure of the tumor cells to 1 or 2 grays (Gy) of X-rays. Furthermore, the level of phosphorylated Ku was analyzed in both the nuclear and cytoplasmic compartment of normal tissue after exposure to 2 Gy of X-rays.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Adducts,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Activated Protein Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ku autoantigen,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PRKDC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/XRCC5 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2484-92
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11745306-Aged,
pubmed-meshheading:11745306-Aged, 80 and over,
pubmed-meshheading:11745306-Antigens, Nuclear,
pubmed-meshheading:11745306-Blotting, Western,
pubmed-meshheading:11745306-Carcinoma, Transitional Cell,
pubmed-meshheading:11745306-DNA Adducts,
pubmed-meshheading:11745306-DNA Helicases,
pubmed-meshheading:11745306-DNA Probes,
pubmed-meshheading:11745306-DNA Repair,
pubmed-meshheading:11745306-DNA-Activated Protein Kinase,
pubmed-meshheading:11745306-DNA-Binding Proteins,
pubmed-meshheading:11745306-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:11745306-Female,
pubmed-meshheading:11745306-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11745306-Humans,
pubmed-meshheading:11745306-Male,
pubmed-meshheading:11745306-Middle Aged,
pubmed-meshheading:11745306-Nuclear Proteins,
pubmed-meshheading:11745306-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11745306-Radiation Injuries,
pubmed-meshheading:11745306-Tumor Cells, Cultured,
pubmed-meshheading:11745306-Urinary Bladder Neoplasms
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pubmed:year |
2001
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pubmed:articleTitle |
Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma.
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pubmed:affiliation |
Section of Toxicology and Biomedical Sciences, ENEA CR Casaccia, Via Anguillarese 301, 00060 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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