Source:http://linkedlifedata.com/resource/pubmed/id/11741836
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
25
|
| pubmed:dateCreated |
2001-12-19
|
| pubmed:abstractText |
Bipolar affective disorder (BPAD), also known as manic depressive illness, is a severe psychiatric disorder characterized by episodes of mania and depression. It has a lifetime prevalence of approximately 1% in all human populations. In order to identify chromosomal regions containing genes that play a role in determining susceptibility to this psychiatric condition, we have conducted a complete genome screen with 382 markers (average marker spacing of 9.3 cM) in a sample of 75 BPAD families which were recruited through an explicit ascertainment scheme. Pedigrees were of German, Israeli and Italian origin, respectively. Parametric and non-parametric linkage analysis was performed. The highest two-point LOD score was obtained on 8q24 (D8S514; LOD score = 3.62), in a region that has not attracted much attention in previous linkage studies of BPAD. The second best finding was seen on 10q25-q26 (D10S217; LOD score = 2.86) and has been reported in independent studies of BPAD. Other regions showing 'suggestive' evidence for linkage localized to 1p33-p36, 2q21-q33, 3p14, 3q26-q27, 6q21-q22, 8p21, 13q11 and 14q12-q13. In addition, we aimed at detecting possible susceptibility loci underlying genomic imprinting by analyzing the autosomal genotype data with the recently developed extension of the GENEHUNTER program, GENEHUNTER-IMPRINTING. Putative paternally imprinted loci were identified in chromosomal regions 2p24-p21 and 2q31-q32. Maternally imprinted susceptibility genes may be located on 14q32 and 16q21-q23.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0964-6906
|
| pubmed:author |
pubmed-author:AlbusMM,
pubmed-author:BaurM PMP,
pubmed-author:Borrmann-HassenbachMM,
pubmed-author:CichonSS,
pubmed-author:FranzenHH,
pubmed-author:FritzeJJ,
pubmed-author:HürterMM,
pubmed-author:HemmesRR,
pubmed-author:KanyasKK,
pubmed-author:KreinerRR,
pubmed-author:LanczikMM,
pubmed-author:LererBB,
pubmed-author:LichtermannDD,
pubmed-author:MüllerD JDJ,
pubmed-author:MaierWW,
pubmed-author:MingesJJ,
pubmed-author:NöthenM MMM,
pubmed-author:ProppingPP,
pubmed-author:ReunerUU,
pubmed-author:RietschelMM,
pubmed-author:Schmidt-WolfGG,
pubmed-author:SchulzeT GTG,
pubmed-author:SchumacherJJ,
pubmed-author:StrauchKK,
pubmed-author:WeigeltBB,
pubmed-author:WienkerT FTF,
pubmed-author:WindemuthCC
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2933-44
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:11741836-Bipolar Disorder,
pubmed-meshheading:11741836-Chromosome Mapping,
pubmed-meshheading:11741836-Chromosomes, Human, Pair 14,
pubmed-meshheading:11741836-Chromosomes, Human, Pair 16,
pubmed-meshheading:11741836-Chromosomes, Human, Pair 2,
pubmed-meshheading:11741836-Chromosomes, Human, Pair 8,
pubmed-meshheading:11741836-DNA,
pubmed-meshheading:11741836-Female,
pubmed-meshheading:11741836-Genetic Predisposition to Disease,
pubmed-meshheading:11741836-Genetic Testing,
pubmed-meshheading:11741836-Genomic Imprinting,
pubmed-meshheading:11741836-Genotype,
pubmed-meshheading:11741836-Humans,
pubmed-meshheading:11741836-Leukocytes,
pubmed-meshheading:11741836-Lod Score,
pubmed-meshheading:11741836-Male,
pubmed-meshheading:11741836-Microsatellite Repeats,
pubmed-meshheading:11741836-Nuclear Family,
pubmed-meshheading:11741836-Pedigree,
pubmed-meshheading:11741836-Phenotype,
pubmed-meshheading:11741836-Veins
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q.
|
| pubmed:affiliation |
Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D-53111 Bonn, Germany. svcichon@uia.ua.ac.be
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|