Linked Life Data

11741327

Source:http://linkedlifedata.com/resource/pubmed/id/11741327

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-12-19
pubmed:abstractText
Mouse mast cell protease (mMCP)-6, mMCP-7 and transmembrane tryptase (TMT) are all tryptases. The normal mi transcription factor (+-MITF) transactivated mMCP-6 gene by binding three consensus motifs in the promoter region, but no MITF-binding motifs were found in the mMCP-7 promoter. Instead, c-Jun transactivated mMCP-7 gene, and +-MITF cooperated with it. The mi-MITF encoded by mutant mi allele inhibited the transactivation by c-Jun and reduced the mMCP-7 promoter activity. Here, the effect of MITF on the TMT gene expression was examined. The +-MITF enhanced the TMT promoter activity by binding two consensus motifs. The mi-MITF showed the inhibitory effect on TMT gene expression. The effect of +-MITF on TMT gene was similar to the effect on mMCP-6 gene, and that of mi-MITF was similar to the effect on mMCP-7 gene. The effects of MITF on TMT gene appeared distinct from its effects on either mMCP-6 or mMCP-7 gene.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
289
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1243-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11741327-Animals, pubmed-meshheading:11741327-Base Sequence, pubmed-meshheading:11741327-Binding Sites, pubmed-meshheading:11741327-Cells, Cultured, pubmed-meshheading:11741327-DNA, Complementary, pubmed-meshheading:11741327-DNA-Binding Proteins, pubmed-meshheading:11741327-Mast Cells, pubmed-meshheading:11741327-Mice, pubmed-meshheading:11741327-Mice, Mutant Strains, pubmed-meshheading:11741327-Mice, Transgenic, pubmed-meshheading:11741327-Microphthalmia-Associated Transcription Factor, pubmed-meshheading:11741327-Promoter Regions, Genetic, pubmed-meshheading:11741327-Serine Endopeptidases, pubmed-meshheading:11741327-Transcription, Genetic, pubmed-meshheading:11741327-Transcription Factors, pubmed-meshheading:11741327-Transfection, pubmed-meshheading:11741327-Tryptases
pubmed:year
2001
pubmed:articleTitle
Effect of MITF on transcription of transmembrane tryptase gene in cultured mast cells of mice.
pubmed:affiliation
Department of Pathology, Osaka University Medical School, Suita, Japan. morii@patho.med.osaka-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't