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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2001-12-4
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pubmed:abstractText |
The stroma of solid tumors is a complex network of different cell types. We analyzed stroma cell interactions in two tumor models during cyclophosphamide (Cy)-induced tumor rejection. In growing tumors, tumor infiltrating macrophages (TIMs) produced interleukin (IL)-10. Beginning 6 h after Cy-treatment T cells in the tumor were inactivated and TIMs switched to interferon (IFN)-gamma production. Both, IL-10 production before and IFN-gamma production after Cy-treatment by TIMs required T cells. With the same kinetics as TIMs started to produce IFN-gamma the tumor vasculature was destroyed which required IFN-gamma receptor expression on host but not tumor cells. These events preceded hemorrhagic necrosis and residual tumor cell elimination by T cells. Together, T cells regulate the function of TIMs and tumor rejection can be induced by disturbing the stroma network.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733570-10221914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733570-10411927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733570-10623821,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11733570-10676654,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11733570-2683264,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11733570-9570556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733570-9625771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733570-9725200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733570-9755873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733570-9858522
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
194
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1549-59
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11733570-Animals,
pubmed-meshheading:11733570-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11733570-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11733570-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11733570-Cyclophosphamide,
pubmed-meshheading:11733570-Fibrosarcoma,
pubmed-meshheading:11733570-Interferon-gamma,
pubmed-meshheading:11733570-Interleukin-10,
pubmed-meshheading:11733570-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:11733570-Macrophages,
pubmed-meshheading:11733570-Mice,
pubmed-meshheading:11733570-Mice, Inbred BALB C,
pubmed-meshheading:11733570-Mice, Knockout,
pubmed-meshheading:11733570-Mice, Nude,
pubmed-meshheading:11733570-Neoplasms, Experimental,
pubmed-meshheading:11733570-Neovascularization, Pathologic,
pubmed-meshheading:11733570-Plasmacytoma,
pubmed-meshheading:11733570-Receptors, Interferon,
pubmed-meshheading:11733570-Stromal Cells,
pubmed-meshheading:11733570-Time Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Tumor rejection by disturbing tumor stroma cell interactions.
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pubmed:affiliation |
Max-Delbrück-Center for Molecular Medicine, 13092 Berlin, Germany.
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