Linked Life Data

1173033

Source:http://linkedlifedata.com/resource/pubmed/id/1173033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1975-5-27
pubmed:abstractText
The study of the biotransformation of 2-(N,N-dimethylaminoethanol)-cyclohexylpropionate-meleate acid (cyprodenate, Actebral), a psychotonic brain stimulant, was carried out on two species of animals (rats and pigs) with the aid of 14C-labelled molecules. Following i.v. administration in rats it was found that 14C-cyprodenate diffuses very rapidly to the principal organs (liver, brain, kidneys) preceding a hydrolysis which gives 14C-dimethylaminoethanol (DMAE). The latter undergoes N-oxidation but the major portion of DMAE goes directly into the metabolic cycle of the phospholipids up to the formation of 14C-choline, as shown in the metabolic scheme proposed by the authors that identifies the principal labelled intermediaries: 14C-phosphoryl-DMAE (P-DMAE), 14C-glycerophosphatidyl-N,N-dimethylethanolamine (GP-DMAE), 14C-glycerophosphatidyl-choline (GP-choline). Similar results were found with the oral administration of 14C-cyprodenate in pigs, thus showing a more intense participation of the product at the level of the intermediary metabolism of phospholipids, precursors of choline.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
201-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals.
pubmed:publicationType
Journal Article