Source:http://linkedlifedata.com/resource/pubmed/id/11720869
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
24
|
| pubmed:dateCreated |
2001-11-26
|
| pubmed:abstractText |
Two novel 3'-substituted carboxycylopropylglycines, (2S,1'S,2'S,3'R)-2-(3'-xanthenylmethyl-2'-carboxycyclopropyl)glycine (8a) and (2S,1'S,2'S,3'R)-2-(3'-xanthenylethyl-2'-carboxycyclopropyl)glycine (8b), were synthesized and evaluated as mGluR ligands. Compound 8b showed to be a potent group II antagonist with submicromolar activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
17
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3179-82
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:11720869-Animals,
pubmed-meshheading:11720869-CHO Cells,
pubmed-meshheading:11720869-Cricetinae,
pubmed-meshheading:11720869-Drug Evaluation, Preclinical,
pubmed-meshheading:11720869-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11720869-Glycine,
pubmed-meshheading:11720869-Receptors, Metabotropic Glutamate
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors.
|
| pubmed:affiliation |
Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo 1, 06127, Perugia, Italy. rp@unipg.it
|
| pubmed:publicationType |
Journal Article
|