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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2001-11-20
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pubmed:abstractText |
Design, synthesis and structure-activity relationship of a class of aryl pyrroles as farnesyltransferase inhibitors are described. In vitro and in vivo evaluation of a panel of these inhibitors led to identification of 2 (LB42908) as a highly potent (IC(50)=0.9 nM against H-Ras and 2.4 nM against K-Ras) antitumor agent that is currently undergoing preclinical studies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ChoiTT,
pubmed-author:ChungH HHH,
pubmed-author:JeongS WSW,
pubmed-author:JundRR,
pubmed-author:KimJ HJH,
pubmed-author:KimKK,
pubmed-author:KooJ HJH,
pubmed-author:LeeHH,
pubmed-author:LeeJJ,
pubmed-author:LeeSS,
pubmed-author:LiuP YPY,
pubmed-author:ParkKK,
pubmed-author:RoSS,
pubmed-author:ShinYY
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3069-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11714612-Alkyl and Aryl Transferases,
pubmed-meshheading:11714612-Animals,
pubmed-meshheading:11714612-Antineoplastic Agents,
pubmed-meshheading:11714612-Dose-Response Relationship, Drug,
pubmed-meshheading:11714612-Drug Design,
pubmed-meshheading:11714612-Drug Screening Assays, Antitumor,
pubmed-meshheading:11714612-Enzyme Inhibitors,
pubmed-meshheading:11714612-Humans,
pubmed-meshheading:11714612-Imidazoles,
pubmed-meshheading:11714612-Inhibitory Concentration 50,
pubmed-meshheading:11714612-Mice,
pubmed-meshheading:11714612-Mice, Nude,
pubmed-meshheading:11714612-Peptides,
pubmed-meshheading:11714612-Piperazines,
pubmed-meshheading:11714612-Structure-Activity Relationship,
pubmed-meshheading:11714612-Tumor Cells, Cultured,
pubmed-meshheading:11714612-Xenograft Model Antitumor Assays
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pubmed:year |
2001
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pubmed:articleTitle |
A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase).
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pubmed:affiliation |
Life Science R&D, LGCI, Science Town, Taejon 305-380, Republic of Korea.
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pubmed:publicationType |
Journal Article
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