Source:http://linkedlifedata.com/resource/pubmed/id/11694827
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2001-11-5
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pubmed:abstractText |
The relationship between HIV-1 replication and hematologic parameters was examined in two separate studies. The first study was a cross-sectional evaluation of 207 untreated patients. In this study, the proportion of patients with hematologic disorders increased with disease progression. There was a significant inverse correlation between HIV-1 plasma viral load and all hematologic values (r = -0.266 to -0.331). The second study was a longitudinal evaluation of patients on combination antiretroviral therapy (HAART) with hematologic alterations before treatment ( N = 27 with platelets <150,000/microl, 24 with hemoglobin <12 g/dl, 36 with neutrophils <2000/microl and 29 with leukocytes <3000/microl). Samples were analyzed every 3 months for 2 years. At 2 years, >50% of patients experienced a sustained virologic response, with viral loads <500 RNA copies/ml. Hematologic reconstitution occurred progressively for all blood cell lineages and became statistically significant after the sixth month of therapy ( p <.001). Mean values increased from 110 to 180 x 10(3)/microl for platelets, from 10.7 to 12.3 g/dl for hemoglobin (stabilizing finally at 11.4 g/dl), from 1,260 to 2,240/microl for neutrophils, and from 2,260 to 3,600/microl for leukocytes. In conclusion, hematologic disorders are corrected by combination antiretroviral therapy. This suggests a causative role of HIV-1 in hematologic disorders.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1525-4135
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11694827-Adult,
pubmed-meshheading:11694827-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:11694827-Cross-Sectional Studies,
pubmed-meshheading:11694827-Female,
pubmed-meshheading:11694827-HIV Infections,
pubmed-meshheading:11694827-HIV Protease Inhibitors,
pubmed-meshheading:11694827-HIV-1,
pubmed-meshheading:11694827-Hematologic Diseases,
pubmed-meshheading:11694827-Humans,
pubmed-meshheading:11694827-Longitudinal Studies,
pubmed-meshheading:11694827-Male,
pubmed-meshheading:11694827-Viral Load,
pubmed-meshheading:11694827-Virus Replication
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pubmed:year |
2001
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pubmed:articleTitle |
HIV-associated hematologic disorders are correlated with plasma viral load and improve under highly active antiretroviral therapy.
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pubmed:affiliation |
Laboratoire de Rétrovirologie, Centre de Recherche Public-Santé, Luxembourg.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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