Linked Life Data

1168208

Source:http://linkedlifedata.com/resource/pubmed/id/1168208

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-6-25
pubmed:abstractText
The involvement of adrenocortical hormones in the amnesic effect of cycloheximide was examined in mice. Subcutaneous injection of cycloheximide shortly before a training trial of a passive avoidance task resulted in an amnesia of the avoidance response. However, amnesia was absent in the adrenalectomized animals in which cerebral protein synthesis was suppressed by cycloheximide. Injection of corticosteroids antagonized the amnesic effect, most effecively if the steroids were given immediately after training. The influence of the hormonal treatments upon the amnesic effect was not ascribable to a change in general activity level. The amnesic effect of subcutaneously injected cycloheximide appears to be mediated by hormonal deficiency, and not related to suppression of the cerebral protein synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9940
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
378-85
pubmed:dateRevised
2009-10-27
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Amnesic effect of cycloheximide in the mouse mediated by adrenocortical hormones.
pubmed:publicationType
Journal Article