|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
22
|
|
pubmed:dateCreated |
2001-10-25
|
|
pubmed:abstractText |
Novel cationic amphiphiles, based on lithocholic acid derivatives with two structural motifs, anchoring lipids and bola lipids, were designed and synthesized. Both bear extended hydrophobic space-filling substituents. A significant effect of the orientation and extension of hydrophobic regions around the ether linkage at the 3-position was found on the efficiency of DNA delivery.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
19
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2897-901
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11677122-3T3 Cells,
pubmed-meshheading:11677122-Animals,
pubmed-meshheading:11677122-Cations,
pubmed-meshheading:11677122-Cholesterol,
pubmed-meshheading:11677122-Lipids,
pubmed-meshheading:11677122-Liposomes,
pubmed-meshheading:11677122-Lithocholic Acid,
pubmed-meshheading:11677122-Luciferases,
pubmed-meshheading:11677122-Mice,
pubmed-meshheading:11677122-Plasmids,
pubmed-meshheading:11677122-Surface-Active Agents,
pubmed-meshheading:11677122-Transfection
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Anchoring and bola cationic amphiphiles for nucleotide delivery. Effects of orientation and extension of hydrophobic regions.
|
|
pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
