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rdf:type |
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lifeskim:mentions |
umls-concept:C0021853,
umls-concept:C0024320,
umls-concept:C0035015,
umls-concept:C0085358,
umls-concept:C0152060,
umls-concept:C0205154,
umls-concept:C0450127,
umls-concept:C0596901,
umls-concept:C0851285,
umls-concept:C1306235,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1548437,
umls-concept:C1706438,
umls-concept:C1882923,
umls-concept:C2698600
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pubmed:issue |
9
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pubmed:dateCreated |
2001-10-23
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pubmed:abstractText |
Blocking the CD28/B7 and/or CD154/CD40 costimulatory pathways promotes long-term allograft survival in many transplant models where CD4(+) T cells are necessary for rejection. When CD8(+) T cells are sufficient to mediate rejection, these approaches fail, resulting in costimulation blockade-resistant rejection. To address this problem we examined the role of lymphotoxin-related molecules in CD8(+) T cell-mediated rejection of murine intestinal allografts. Targeting membrane lymphotoxin by means of a fusion protein, mAb, or genetic mutation inhibited rejection of intestinal allografts by CD8(+) T cells. This effect was associated with decreased monokine induced by IFN-gamma (Mig) and secondary lymphoid chemokine (SLC) gene expression within allografts and spleens respectively. Blocking membrane lymphotoxin did not inhibit rejection mediated by CD4(+) T cells. Combining disruption of membrane lymphotoxin and treatment with CTLA4-Ig inhibited rejection in wild-type mice. These data demonstrate that membrane lymphotoxin is an important regulatory molecule for CD8(+) T cells mediating rejection and suggest a strategy to avoid costimulation blockade-resistant rejection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf14 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf14 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor Ligand...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:AlegreM LML,
pubmed-author:FOXJ VJV,
pubmed-author:FuY XYX,
pubmed-author:GuyPP,
pubmed-author:HaroGG,
pubmed-author:KiiKK,
pubmed-author:MengLL,
pubmed-author:NewellK AKA,
pubmed-author:POET HTH,
pubmed-author:ThistlethwaiteJ RJRJr,
pubmed-author:WangJJ,
pubmed-author:ZhouPP
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4796-800
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11673481-Animals,
pubmed-meshheading:11673481-Antigens, CD,
pubmed-meshheading:11673481-Antigens, Differentiation,
pubmed-meshheading:11673481-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11673481-CTLA-4 Antigen,
pubmed-meshheading:11673481-Graft Rejection,
pubmed-meshheading:11673481-Immunoconjugates,
pubmed-meshheading:11673481-Intestines,
pubmed-meshheading:11673481-Lymphotoxin-alpha,
pubmed-meshheading:11673481-Membrane Proteins,
pubmed-meshheading:11673481-Mice,
pubmed-meshheading:11673481-Mice, Inbred C3H,
pubmed-meshheading:11673481-Mice, Inbred C57BL,
pubmed-meshheading:11673481-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:11673481-Receptors, Tumor Necrosis Factor, Member 14,
pubmed-meshheading:11673481-Receptors, Virus,
pubmed-meshheading:11673481-Transplantation, Homologous,
pubmed-meshheading:11673481-Tumor Necrosis Factor Ligand Superfamily Member 14,
pubmed-meshheading:11673481-Tumor Necrosis Factor-alpha
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pubmed:year |
2001
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pubmed:articleTitle |
Cutting edge: membrane lymphotoxin regulates CD8(+) T cell-mediated intestinal allograft rejection.
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pubmed:affiliation |
Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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