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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2001-10-30
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pubmed:abstractText |
A key step in T cell development involves the positive selection of cells that recognize antigen presented by self-major histocompatibility complex. Yet, the signals that are activated by T cell receptor engagement and lead to cell survival remain unclear. We show here that mice lacking the transcription factor Schnurri-2 (Shn-2), a large metal-finger protein, had severely defective positive selection of CD4+ and CD8+ cells. Drosophila Shn acts as a cofactor of Smad homolog and is required for Decapentaplegic signaling. Vertebrates have at least three Shn orthologs (Shn-1, Shn-2 and Shn-3), which are thought to act as nuclear targets in the bone morphogenetic protein-transforming growth factor-beta-activin signaling pathways. These data raised the possibility that the Smad-Shn-2 complex is involved in the thymic selection of T cells.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Activins,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HIVEP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HIVEP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HIVEP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hivep3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/MAD protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Medea protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Smad4 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/dpp protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/schnurri protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1048-53
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pubmed:dateRevised |
2007-11-8
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pubmed:meshHeading |
pubmed-meshheading:11668343-Activins,
pubmed-meshheading:11668343-Animals,
pubmed-meshheading:11668343-Bone Marrow Cells,
pubmed-meshheading:11668343-Bone Marrow Transplantation,
pubmed-meshheading:11668343-Bone Morphogenetic Proteins,
pubmed-meshheading:11668343-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11668343-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11668343-Carrier Proteins,
pubmed-meshheading:11668343-Clonal Deletion,
pubmed-meshheading:11668343-DNA-Binding Proteins,
pubmed-meshheading:11668343-Drosophila Proteins,
pubmed-meshheading:11668343-Drosophila melanogaster,
pubmed-meshheading:11668343-Epithelial Cells,
pubmed-meshheading:11668343-Female,
pubmed-meshheading:11668343-Gene Expression Regulation, Developmental,
pubmed-meshheading:11668343-Gene Targeting,
pubmed-meshheading:11668343-Male,
pubmed-meshheading:11668343-Mice,
pubmed-meshheading:11668343-Mice, Inbred BALB C,
pubmed-meshheading:11668343-Mice, Inbred C57BL,
pubmed-meshheading:11668343-Mice, Knockout,
pubmed-meshheading:11668343-NF-kappa B,
pubmed-meshheading:11668343-Radiation Chimera,
pubmed-meshheading:11668343-Self Tolerance,
pubmed-meshheading:11668343-Signal Transduction,
pubmed-meshheading:11668343-Smad4 Protein,
pubmed-meshheading:11668343-Species Specificity,
pubmed-meshheading:11668343-Spleen,
pubmed-meshheading:11668343-Stromal Cells,
pubmed-meshheading:11668343-T-Lymphocyte Subsets,
pubmed-meshheading:11668343-Thymus Gland,
pubmed-meshheading:11668343-Trans-Activators,
pubmed-meshheading:11668343-Transcription Factors,
pubmed-meshheading:11668343-Transforming Growth Factor beta
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pubmed:year |
2001
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pubmed:articleTitle |
Murine Schnurri-2 is required for positive selection of thymocytes.
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pubmed:affiliation |
Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, CREST Research Project of JST, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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