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rdf:type |
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lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0021853,
umls-concept:C0026565,
umls-concept:C0026724,
umls-concept:C0034693,
umls-concept:C0132555,
umls-concept:C0205263,
umls-concept:C0332293,
umls-concept:C0442805,
umls-concept:C0729218,
umls-concept:C1883709
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pubmed:issue |
4
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|
pubmed:dateCreated |
2001-10-22
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pubmed:abstractText |
Despite the beneficial immunosuppressive effects of FK506 during small intestine transplantation, FK506 appears to have direct toxic effects on the intestine. The mechanisms of FK506-induced intestinal damage is unclear, and whether nitric oxide (NO) is involved in the mechanism has not been well defined. This study was designed to evaluate the effects of NG-Nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthase, on small intestinal damage in rats treated with FK506.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0940-2993
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
297-301
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11665854-Administration, Oral,
pubmed-meshheading:11665854-Animals,
pubmed-meshheading:11665854-Body Weight,
pubmed-meshheading:11665854-Diarrhea,
pubmed-meshheading:11665854-Drinking,
pubmed-meshheading:11665854-Drug Antagonism,
pubmed-meshheading:11665854-Enzyme Inhibitors,
pubmed-meshheading:11665854-Immunosuppressive Agents,
pubmed-meshheading:11665854-Injections, Intramuscular,
pubmed-meshheading:11665854-Intestinal Mucosa,
pubmed-meshheading:11665854-Jejunum,
pubmed-meshheading:11665854-Longevity,
pubmed-meshheading:11665854-Male,
pubmed-meshheading:11665854-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:11665854-Nitric Oxide Synthase,
pubmed-meshheading:11665854-Rats,
pubmed-meshheading:11665854-Rats, Wistar,
pubmed-meshheading:11665854-Tacrolimus,
pubmed-meshheading:11665854-Time Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Inhibition of nitric oxide synthase induces intestinal mucosal damage and increases mortality in rats treated by FK506.
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pubmed:affiliation |
Department of Urology, Yamanashi Medical University, Japan. wangl@res.yamanashi-med.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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