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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-10-16
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pubmed:abstractText |
The effects of prenatal CO exposure (150 ppm from days 0 to 20 of pregnancy) on the postnatal development of hippocampal neuronal NO synthase (nNOS) and haem-oxygenase (HO-2) isoform activities in 15-, 30- and 90-d-old rats were investigated. Unlike HO-2, hippocampal nNOS activity increased from postnatal days 15-90 in controls. Prenatal CO produced a long-lasting decrease in either nNOS or HO-2. The results suggest that the altered developmental profile of hippocampal nNOS and HO-2 activities could be involved in cognitive deficits and long-term potentiation dysfunction exhibited by rats prenatally exposed to CO levels resulting in carboxyhaemoglobin (HbCO) levels equivalent to those observed in human cigarette smokers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1461-1457
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pubmed:author |
pubmed-author:CagianoRR,
pubmed-author:ColucciaAA,
pubmed-author:CuomoVV,
pubmed-author:MereuGG,
pubmed-author:OokT HTH,
pubmed-author:RuizHH,
pubmed-author:SabaPP,
pubmed-author:SteardoLL,
pubmed-author:TattoliMM,
pubmed-author:TrabaceLL,
pubmed-author:VaccariAA
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11602027-Animals,
pubmed-meshheading:11602027-Carbon Monoxide,
pubmed-meshheading:11602027-Female,
pubmed-meshheading:11602027-Heme Oxygenase (Decyclizing),
pubmed-meshheading:11602027-Hemoglobins,
pubmed-meshheading:11602027-Hippocampus,
pubmed-meshheading:11602027-Isoenzymes,
pubmed-meshheading:11602027-Nitric Oxide Synthase,
pubmed-meshheading:11602027-Nitric Oxide Synthase Type I,
pubmed-meshheading:11602027-Pregnancy,
pubmed-meshheading:11602027-Prenatal Exposure Delayed Effects,
pubmed-meshheading:11602027-Rats,
pubmed-meshheading:11602027-Rats, Wistar
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pubmed:year |
2001
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pubmed:articleTitle |
Prenatal low-level exposure to CO alters postnatal development of hippocampal nitric oxide synthase and haem-oxygenase activities in rats.
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pubmed:affiliation |
Bernard B. Brodie Department of Neuroscience, Via Porcell 4, 09124 Cagliari, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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