Source:http://linkedlifedata.com/resource/pubmed/id/11601139
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2001-10-16
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| pubmed:abstractText |
We correlated bone marrow cytogenetic findings with morphologic and immunophenotypic data in 37 patients with lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM). Each LPL/WM case was classified as lymphoplasmacytoid (n = 18), lymphoplasmacytic (n = 10), or polymorphous (n = 9) using the Kiel criteria. Of 12 cases with chromosomal abnormalities, a single numeric abnormality was present in 4 and a complex karyotype in 8. The most common numeric abnormalities were and -8 in 3 cases each; the most common structural abnormality was del(6q) in 6 cases. Cytogenetic abnormalities were significantly less common in the lymphoplasmacytic and lymphoplasmacytoid groups (5/28 [18%]) compared with the polymorphous group (7/9 [78%]). Clinical follow-up was available for 28 patients for a median of 36 months. Six (67%) of 9 patients with aneuploid tumors, including 4 with polymorphous subtype, subsequently had clinical progression or developed high-grade lymphoma. In contrast, 4 (21%) of 19 patients with diploid tumors, including 1 of polymorphous type, developed clinical progression or high-grade lymphoma. We conclude that abnormal cytogenetic findings in LPL/WM correlate with the polymorphous subtype and poor prognosis.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0002-9173
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
116
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
543-9
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11601139-Adult,
pubmed-meshheading:11601139-Aged,
pubmed-meshheading:11601139-Bone Marrow Cells,
pubmed-meshheading:11601139-Chromosome Aberrations,
pubmed-meshheading:11601139-Chromosomes, Human, Pair 6,
pubmed-meshheading:11601139-Chromosomes, Human, Pair 8,
pubmed-meshheading:11601139-Cytogenetic Analysis,
pubmed-meshheading:11601139-Female,
pubmed-meshheading:11601139-Gene Deletion,
pubmed-meshheading:11601139-Humans,
pubmed-meshheading:11601139-Immunophenotyping,
pubmed-meshheading:11601139-Karyotyping,
pubmed-meshheading:11601139-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:11601139-Male,
pubmed-meshheading:11601139-Middle Aged,
pubmed-meshheading:11601139-Ploidies,
pubmed-meshheading:11601139-Prognosis,
pubmed-meshheading:11601139-Trisomy,
pubmed-meshheading:11601139-Waldenstrom Macroglobulinemia,
pubmed-meshheading:11601139-Y Chromosome
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| pubmed:year |
2001
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| pubmed:articleTitle |
Cytogenetic findings in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical course.
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| pubmed:affiliation |
Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
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| pubmed:publicationType |
Journal Article
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