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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2001-10-12
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pubmed:abstractText |
Activation of the coagulation system and depletion of endogenous anticoagulants are frequently found in patients with severe sepsis and septic shock. Diffuse microthrombus formation may induce organ dysfunction and lead to excess mortality in septic shock. Antithrombin III may provide protection from multiorgan failure and improve survival in severely ill patients.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0098-7484
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pubmed:author |
pubmed-author:AtherstoneAA,
pubmed-author:BoneR CRC,
pubmed-author:CarrVV,
pubmed-author:ChalupaPP,
pubmed-author:EidAA,
pubmed-author:HeinrichsHH,
pubmed-author:JuersMM,
pubmed-author:KüblerAA,
pubmed-author:KeineckeH OHO,
pubmed-author:KnaufWW,
pubmed-author:KyberSept Trial Study Group,
pubmed-author:NovakII,
pubmed-author:OpalS MSM,
pubmed-author:PénzesII,
pubmed-author:PillayS SSS,
pubmed-author:SchindelFF,
pubmed-author:SingerPP,
pubmed-author:WarrenB LBL
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1869-78
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11597289-Adult,
pubmed-meshheading:11597289-Anticoagulants,
pubmed-meshheading:11597289-Antithrombin III,
pubmed-meshheading:11597289-Double-Blind Method,
pubmed-meshheading:11597289-Drug Interactions,
pubmed-meshheading:11597289-Female,
pubmed-meshheading:11597289-Heparin,
pubmed-meshheading:11597289-Humans,
pubmed-meshheading:11597289-Male,
pubmed-meshheading:11597289-Multiple Organ Failure,
pubmed-meshheading:11597289-Serine Proteinase Inhibitors,
pubmed-meshheading:11597289-Shock, Septic,
pubmed-meshheading:11597289-Survival Analysis,
pubmed-meshheading:11597289-Systemic Inflammatory Response Syndrome,
pubmed-meshheading:11597289-Thrombosis
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pubmed:year |
2001
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pubmed:articleTitle |
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial.
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pubmed:affiliation |
Brown University School of Medicine, Infectious Disease Division, Memorial Hospital of Rhode Island, 111 Brewster St, Pawtucket, RI 02860, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase III
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