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rdf:type |
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lifeskim:mentions |
umls-concept:C0013030,
umls-concept:C0017262,
umls-concept:C0025611,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0235032,
umls-concept:C0591833,
umls-concept:C0751608,
umls-concept:C1335271,
umls-concept:C1709016,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
2001-10-10
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824471,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824475,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824488,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824509,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824514,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824515,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824534,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824540,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824543,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824549,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824580,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824608,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824623,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824737,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824847,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824874,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824891,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824897,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824908,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE824917,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BE825801
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pubmed:abstractText |
Due to brain tissue heterogeneity, the molecular genetic profile of any neurotransmitter-specific neuronal subtype is unknown. The purpose of this study was to purify a population of dopamine neurons, construct a cDNA library, and generate an initial gene expression profile and a microarray representative of dopamine neuron transcripts. Ventral mesencephalic dopamine neurons were purified by fluorescent-activated cell sorting from embryonic day 13.5 transgenic mice harboring a 4.5-kb rat tyrosine hydroxylase promoter-lacZ fusion. Nine-hundred sixty dopamine neuron cDNA clones were sequenced and arrayed for use in studies of gene expression changes during methamphetamine neurotoxicity. A neurotoxic dose of methamphetamine produced a greater than twofold up-regulation of the mitochondrial cytochrome c oxidase polypeptide I transcript from adult mouse substantia nigra at 12 h posttreatment. This is the first work to describe a gene expression profile for a neuronal subtype and to identify gene expression changes during methamphetamine neurotoxicity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0969-9961
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pubmed:author |
pubmed-author:BarrettTT,
pubmed-author:BeckerK GKG,
pubmed-author:CheadleCC,
pubmed-author:ChrestF JFJ,
pubmed-author:Dillon-CarterOO,
pubmed-author:DonovanD MDM,
pubmed-author:FreedW JWJ,
pubmed-author:JuhaszovaMM,
pubmed-author:KargulG JGJ,
pubmed-author:KoM SMS,
pubmed-author:LiuM CMC,
pubmed-author:McCannU DUD,
pubmed-author:PiaoYY,
pubmed-author:RicaurteG AGA,
pubmed-author:RowleyD LDL,
pubmed-author:VawterM PMP,
pubmed-author:WerstoRR,
pubmed-author:WoodW HWH3rd,
pubmed-author:XieTT,
pubmed-author:ZhouLL
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
822-33
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11592851-Animals,
pubmed-meshheading:11592851-Mice,
pubmed-meshheading:11592851-Rats,
pubmed-meshheading:11592851-Neurons,
pubmed-meshheading:11592851-Methamphetamine,
pubmed-meshheading:11592851-Female,
pubmed-meshheading:11592851-Male,
pubmed-meshheading:11592851-Electron Transport Complex IV,
pubmed-meshheading:11592851-Mesencephalon,
pubmed-meshheading:11592851-Nerve Tissue Proteins,
pubmed-meshheading:11592851-Dopamine,
pubmed-meshheading:11592851-Enzyme Induction,
pubmed-meshheading:11592851-Molecular Sequence Data,
pubmed-meshheading:11592851-Transcription, Genetic,
pubmed-meshheading:11592851-Tyrosine 3-Monooxygenase,
pubmed-meshheading:11592851-Promoter Regions, Genetic,
pubmed-meshheading:11592851-Lac Operon,
pubmed-meshheading:11592851-DNA, Complementary,
pubmed-meshheading:11592851-3,4-Dihydroxyphenylacetic Acid,
pubmed-meshheading:11592851-Dopamine Uptake Inhibitors,
pubmed-meshheading:11592851-Genes, Synthetic,
pubmed-meshheading:11592851-Gene Expression Profiling
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