|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0009171,
umls-concept:C0013216,
umls-concept:C0026548,
umls-concept:C0035647,
umls-concept:C0205430,
umls-concept:C0220781,
umls-concept:C0243072,
umls-concept:C0243076,
umls-concept:C0243192,
umls-concept:C1510827,
umls-concept:C1518591,
umls-concept:C1883254
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|
pubmed:issue |
20
|
|
pubmed:dateCreated |
2001-10-9
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|
pubmed:abstractText |
A series of new N-substituted derivatives of morphinan was synthesized and their binding affinity for the three opioid receptors (mu, delta, and kappa) was determined. A paradoxical effect of N-propargyl (MCL-117) and N-(3-iodoprop-(2E)-enyl) (MCL-118) substituents on the binding affinities for the mu and kappa opioid receptors was observed. All of these novel derivatives showed a preference for the mu and kappa versus delta binding.
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pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:day |
22
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2735-40
|
|
pubmed:dateRevised |
2007-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:11591513-Cocaine-Related Disorders,
pubmed-meshheading:11591513-Drug Combinations,
pubmed-meshheading:11591513-Humans,
pubmed-meshheading:11591513-Morphinans,
pubmed-meshheading:11591513-Narcotic Antagonists,
pubmed-meshheading:11591513-Receptors, Opioid, kappa,
pubmed-meshheading:11591513-Receptors, Opioid, mu
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan.
|
|
pubmed:affiliation |
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. neumeyer@mclean.harvard.edu
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
