Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-10-9
pubmed:abstractText
The pivotal role of the platelets in the genesis of acute coronary syndromes emphasises the importance of an early and sustained antiplatelet therapy. The CURE trial shows that clopidogrel in addition to aspirin achieves this double goal, with a 20% relative risk reduction in the primary composite endpoint of cardiovascular death, myocardial infarction or stroke in the first 30 days. The benefits are apparent as early as the first 24 hours of starting the treatment. There is also a consistent benefit of clopidogrel across all groups, including both high-risk and low-risk patients, which overrides an excess of 6 out of a thousand cases treated per year of bleeds, which require transfusion. Several clinical implications of the CURE trial are analyzed: the kind of patients who benefit more on clopidogrel, how long should treatment with clopidogrel continue, cost-benefit consideration, the impact of the findings on the benefit of the use of clopidogrel, on the use of glycoprotein IIb/IIIa receptor antagonists, clopidogrel pretreatment and long term therapy in patients undergoing percutaneous coronary intervention and bleeding risk with surgery.
pubmed:commentsCorrections
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0300-8932
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1127-34
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed-meshheading:11591313-Angina, Unstable, pubmed-meshheading:11591313-Aspirin, pubmed-meshheading:11591313-Cost-Benefit Analysis, pubmed-meshheading:11591313-Drug Therapy, Combination, pubmed-meshheading:11591313-Female, pubmed-meshheading:11591313-Humans, pubmed-meshheading:11591313-Male, pubmed-meshheading:11591313-Middle Aged, pubmed-meshheading:11591313-Multicenter Studies as Topic, pubmed-meshheading:11591313-Myocardial Infarction, pubmed-meshheading:11591313-Patient Selection, pubmed-meshheading:11591313-Platelet Aggregation Inhibitors, pubmed-meshheading:11591313-Platelet Glycoprotein GPIIb-IIIa Complex, pubmed-meshheading:11591313-Randomized Controlled Trials as Topic, pubmed-meshheading:11591313-Syndrome, pubmed-meshheading:11591313-Ticlopidine, pubmed-meshheading:11591313-Treatment Outcome
pubmed:year
2001
pubmed:articleTitle
[Clopidogrel in acute coronary syndromes with non-ST elevation. Clinical implications of the CURE trial].
pubmed:publicationType
Editorial, English Abstract