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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-10-3
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pubmed:abstractText |
Chemokine production by tumors is a well-known phenomenon, but its role in tumor biology remains debatable. Although intratumoral injection of granulocyte chemotactic protein-2 (GCP-2) had no effect on tumor parameters, needle-free stable expression of the chemokine resulted in enhanced tumor growth. It is shown here that tumors that express a potent form of GCP-2 induce a strong influx and activation of tumor-associated neutrophils. The production of GCP-2 leads to intratumoral expression of gelatinase B and advantage for tumor growth by increased angiogenesis. These results are in line with the countercurrent principle of chemokine action and support the notion that paraneoplastic expression of ELR-positive CXC chemokines has to be blocked rather than stimulated in cancer therapy.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-10570306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-10647998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-10714678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-10786697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-10815938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-10914483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-11023497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-11081634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-11175849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-11175850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-11229684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-1281554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-1298279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-1388654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-1613466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-1908075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-1918013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-2169896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-2182547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-2781291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-3258625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-6828888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-7592998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-7622488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-8304236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-8423327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-8475106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-8574748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-8756718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-8759763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-9008168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-942051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11583968-9730840
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1405-14
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11583968-Animals,
pubmed-meshheading:11583968-Chemokine CXCL6,
pubmed-meshheading:11583968-Chemokines, CXC,
pubmed-meshheading:11583968-Chemotaxis, Leukocyte,
pubmed-meshheading:11583968-Female,
pubmed-meshheading:11583968-Gene Transfer Techniques,
pubmed-meshheading:11583968-Humans,
pubmed-meshheading:11583968-Injections, Intralesional,
pubmed-meshheading:11583968-Melanoma,
pubmed-meshheading:11583968-Mice,
pubmed-meshheading:11583968-Mice, Nude,
pubmed-meshheading:11583968-Neoplasm Transplantation,
pubmed-meshheading:11583968-Neovascularization, Pathologic,
pubmed-meshheading:11583968-Neutrophils,
pubmed-meshheading:11583968-Peptide Fragments,
pubmed-meshheading:11583968-Recombinant Proteins,
pubmed-meshheading:11583968-Skin Neoplasms,
pubmed-meshheading:11583968-Transfection
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pubmed:year |
2001
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pubmed:articleTitle |
Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle.
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pubmed:affiliation |
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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