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rdf:type |
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lifeskim:mentions |
umls-concept:C0018296,
umls-concept:C0034790,
umls-concept:C0871261,
umls-concept:C0936012,
umls-concept:C1446409,
umls-concept:C1515432,
umls-concept:C1515655,
umls-concept:C1704632,
umls-concept:C1704735,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
7
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pubmed:dateCreated |
2001-10-2
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pubmed:abstractText |
Loss of function of the guanine nucleotide binding protein RhoA blocks pre-T cell differentiation and survival indicating that this GTPase is a critical signaling molecule during early thymocyte development. Previous work has shown that the Rho family GTPase Rac-1 can initiate changes in actin dynamics necessary and sufficient for pre-T cell development. The present data now show that Rac-1 actions in pre-T cells require Rho function but that RhoA cannot substitute for Rac-1 and induce the actin cytoskeletal changes necessary for pre-T cell development. Activation of Rho is thus not sufficient to induce pre-T cell differentiation or survival in the absence of the pre-T cell receptor (TCR). The failure of RhoA activation to impact on pre-TCR-mediated signaling was in marked contrast to its actions on T cell responses mediated by the mature TCR alpha/beta complex. Cells expressing active RhoA were thus hyperresponsive in the context of TCR-induced proliferation in vitro and in vivo showed augmented positive selection of thymocytes expressing defined TCR complexes. This reveals that RhoA function is not only important for pre-T cells but also plays a role in determining the fate of mature T cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-10322152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-10358775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-10375531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-10441211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-10556816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-10644975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-10880528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-10925269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-10952314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-11017108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-11093158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-1547488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-1579166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-3260350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-7536630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-7665895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-7700358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-7700360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-8163937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-8268134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-8584934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-8691136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-8990121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-8994827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9099797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9171353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9208843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9252129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9308960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9354466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9572735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9601639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9601640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9602311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9710582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11581313-9730894
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
194
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
903-14
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11581313-Animals,
pubmed-meshheading:11581313-Antigens, CD2,
pubmed-meshheading:11581313-Cell Differentiation,
pubmed-meshheading:11581313-Cells, Cultured,
pubmed-meshheading:11581313-Female,
pubmed-meshheading:11581313-Hematopoietic Stem Cells,
pubmed-meshheading:11581313-Humans,
pubmed-meshheading:11581313-Locus Control Region,
pubmed-meshheading:11581313-Lymphocyte Activation,
pubmed-meshheading:11581313-Mice,
pubmed-meshheading:11581313-Mice, Transgenic,
pubmed-meshheading:11581313-Mutation,
pubmed-meshheading:11581313-Receptors, Antigen, T-Cell,
pubmed-meshheading:11581313-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:11581313-Signal Transduction,
pubmed-meshheading:11581313-Spleen,
pubmed-meshheading:11581313-T-Lymphocytes,
pubmed-meshheading:11581313-Thymus Gland,
pubmed-meshheading:11581313-rac1 GTP-Binding Protein,
pubmed-meshheading:11581313-rhoA GTP-Binding Protein
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pubmed:year |
2001
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pubmed:articleTitle |
Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo.
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pubmed:affiliation |
Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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