| pubmed-article:11563062 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11563062 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11563062 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:11563062 | lifeskim:mentions | umls-concept:C0028953 | lld:lifeskim |
| pubmed-article:11563062 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:11563062 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:11563062 | lifeskim:mentions | umls-concept:C2346501 | lld:lifeskim |
| pubmed-article:11563062 | lifeskim:mentions | umls-concept:C0961954 | lld:lifeskim |
| pubmed-article:11563062 | lifeskim:mentions | umls-concept:C1100939 | lld:lifeskim |
| pubmed-article:11563062 | pubmed:issue | 4-7 | lld:pubmed |
| pubmed-article:11563062 | pubmed:dateCreated | 2001-9-20 | lld:pubmed |
| pubmed-article:11563062 | pubmed:abstractText | The HIV-1 Tat protein interaction with its RNA recognition sequence TAR is an important drug target and model system for the development of specific RNA-protein inhibitors. 2'-O-methyl oligoribonucleotides complementary to the TAR apical stem-loop effectively block Tat binding in vitro. Substitution by 5-propynylC or 5-methylC LNA monomeric units into a 12-mer 2'-O-methyl oligoribonucleotide leads to stronger inhibition, as does a 12-mer PNA. 10-16 mer 2'-O-methyl oligoribonucleotides give sequence- and dose-dependent inhibition of Tat-dependent transcription of an HIV DNA template in HeLa cell nuclear extract. Inhibition is maintained for the substituted 12-mer analogues but is poorer for PNA and is not correlated with TAR binding strength. | lld:pubmed |
| pubmed-article:11563062 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11563062 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11563062 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11563062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11563062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11563062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11563062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11563062 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11563062 | pubmed:issn | 1525-7770 | lld:pubmed |
| pubmed-article:11563062 | pubmed:author | pubmed-author:GaitM JMJ | lld:pubmed |
| pubmed-article:11563062 | pubmed:author | pubmed-author:LimPP | lld:pubmed |
| pubmed-article:11563062 | pubmed:author | pubmed-author:WengerPP | lld:pubmed |
| pubmed-article:11563062 | pubmed:author | pubmed-author:RajwanshiV... | lld:pubmed |
| pubmed-article:11563062 | pubmed:author | pubmed-author:ArzumanovAA | lld:pubmed |
| pubmed-article:11563062 | pubmed:author | pubmed-author:WalshA PAP | lld:pubmed |
| pubmed-article:11563062 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11563062 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11563062 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11563062 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11563062 | pubmed:pagination | 471-80 | lld:pubmed |
| pubmed-article:11563062 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11563062 | pubmed:meshHeading | pubmed-meshheading:11563062... | lld:pubmed |
| pubmed-article:11563062 | pubmed:meshHeading | pubmed-meshheading:11563062... | lld:pubmed |
| pubmed-article:11563062 | pubmed:meshHeading | pubmed-meshheading:11563062... | lld:pubmed |
| pubmed-article:11563062 | pubmed:meshHeading | pubmed-meshheading:11563062... | lld:pubmed |
| pubmed-article:11563062 | pubmed:meshHeading | pubmed-meshheading:11563062... | lld:pubmed |
| pubmed-article:11563062 | pubmed:meshHeading | pubmed-meshheading:11563062... | lld:pubmed |
| pubmed-article:11563062 | pubmed:meshHeading | pubmed-meshheading:11563062... | lld:pubmed |
| pubmed-article:11563062 | pubmed:meshHeading | pubmed-meshheading:11563062... | lld:pubmed |
| pubmed-article:11563062 | pubmed:articleTitle | Oligonucleotide analogue interference with the HIV-1 Tat protein-TAR RNA interaction. | lld:pubmed |
| pubmed-article:11563062 | pubmed:affiliation | Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, U.K. | lld:pubmed |
| pubmed-article:11563062 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11563062 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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