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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-9-28
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pubmed:abstractText |
Interactions with self-major histocompatibility complex molecules on dendritic cells (DCs) are important for the survival of mature CD4+ T cells. We have followed the DC-mediated signal from the T cell surface to the nucleus and identified a pattern of activation that correlates with increased in vitro survival. This response is induced exclusively by DCs and is likely associated with a modulation of the T cell activation threshold. We have also found that DC-mediated activation results in antigen-independent cytokine gene expression, which points to a new role for DCs in shaping the cytokine milieu. Such antigen-independent activation of T cells may play a role in protective immunity, but may also induce and perpetuate autoimmune states such as multiple sclerosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP-70 Protein-Tyrosine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP70 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
932-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11561182-Antigens,
pubmed-meshheading:11561182-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:11561182-Cell Differentiation,
pubmed-meshheading:11561182-Cell Survival,
pubmed-meshheading:11561182-Cells, Cultured,
pubmed-meshheading:11561182-Clone Cells,
pubmed-meshheading:11561182-Dendritic Cells,
pubmed-meshheading:11561182-Humans,
pubmed-meshheading:11561182-Interferon-gamma,
pubmed-meshheading:11561182-Lymphocyte Activation,
pubmed-meshheading:11561182-Protein-Tyrosine Kinases,
pubmed-meshheading:11561182-RNA, Messenger,
pubmed-meshheading:11561182-Receptors, Antigen, T-Cell,
pubmed-meshheading:11561182-Receptors, Interleukin,
pubmed-meshheading:11561182-Receptors, Interleukin-12,
pubmed-meshheading:11561182-Signal Transduction,
pubmed-meshheading:11561182-T-Lymphocytes,
pubmed-meshheading:11561182-ZAP-70 Protein-Tyrosine Kinase
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pubmed:year |
2001
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pubmed:articleTitle |
Dendritic cells signal T cells in the absence of exogenous antigen.
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pubmed:affiliation |
Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1400, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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