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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-9-18
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pubmed:abstractText |
Several studies have shown that melanin-concentrating hormone (MCH) is an orexigenic peptide in rat. In the present study, a structure-activity relationship with MCH analogs was performed in rat, both in vitro and in vivo. On rat recombinant SLC-1 receptor, both cAMP inhibition and [(125)I]S36057 binding were measured. In vivo, these analogs were injected intracerebroventricularly in rats and their effects were evaluated upon food intake. First, data obtained with the rat recombinant receptor were highly correlated with those obtained from its human counterpart. Second, agonist potencies in the cAMP assay were also highly correlated with binding affinities. These peptides could be classified into several groups according to their potency at the SLC-1 receptor (from subnanomolar activity to complete inactivity). Indeed, there was a strong correlation between their effects upon food intake and the results obtained at the rat SLC-1 receptor. The present report describes for the first time the rat SLC-1 receptor pharmacology and clearly establishes the relevance of the SLC-1 receptor in feeding behavior.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-iodotyrosyl-8-amino-3,6-dioxyoctan...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Hypothalamic Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Mch1r protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Melanins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pituitary Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Poly A,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatostatin,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/melanin-concentrating hormone
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-3565
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pubmed:author |
pubmed-author:AudinotVV,
pubmed-author:BeauvergerPP,
pubmed-author:BoutinJ AJA,
pubmed-author:CanetEE,
pubmed-author:Della ZuanaOO,
pubmed-author:DuhaultJJ,
pubmed-author:GalizziJ PJP,
pubmed-author:LeventMM,
pubmed-author:NahonJ LJL,
pubmed-author:RodriguezMM,
pubmed-author:SuplyTT
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pubmed:issnType |
Print
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pubmed:volume |
299
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-46
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11561073-Animals,
pubmed-meshheading:11561073-Cell Line,
pubmed-meshheading:11561073-Cell Membrane,
pubmed-meshheading:11561073-Cloning, Molecular,
pubmed-meshheading:11561073-Cyclic AMP,
pubmed-meshheading:11561073-Feeding Behavior,
pubmed-meshheading:11561073-Hypothalamic Hormones,
pubmed-meshheading:11561073-Injections, Intraventricular,
pubmed-meshheading:11561073-Male,
pubmed-meshheading:11561073-Melanins,
pubmed-meshheading:11561073-Oligopeptides,
pubmed-meshheading:11561073-Pituitary Hormones,
pubmed-meshheading:11561073-Poly A,
pubmed-meshheading:11561073-RNA, Messenger,
pubmed-meshheading:11561073-Rats,
pubmed-meshheading:11561073-Rats, Wistar,
pubmed-meshheading:11561073-Receptors, Somatostatin,
pubmed-meshheading:11561073-Recombinant Proteins,
pubmed-meshheading:11561073-Structure-Activity Relationship
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pubmed:year |
2001
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pubmed:articleTitle |
SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study.
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pubmed:affiliation |
Division de Pharmacologie Moleculaire et Cellulaire, Institut de Recherches Servier, Croissy/Seine, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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