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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5537
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pubmed:dateCreated |
2001-9-14
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pubmed:abstractText |
Transcription factor TFIID, composed of TBP and TAFII subunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary. Female mice lacking TAFII105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAFII105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient ovaries. Together, these studies suggest that TAFII105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAFII105 as a cell type-specific component of the mammalian transcriptional machinery.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
293
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2084-7
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:11557891-Animals,
pubmed-meshheading:11557891-DNA-Binding Proteins,
pubmed-meshheading:11557891-Down-Regulation,
pubmed-meshheading:11557891-Female,
pubmed-meshheading:11557891-Gene Expression Profiling,
pubmed-meshheading:11557891-Gene Expression Regulation, Developmental,
pubmed-meshheading:11557891-Granulosa Cells,
pubmed-meshheading:11557891-In Situ Hybridization,
pubmed-meshheading:11557891-Infertility, Female,
pubmed-meshheading:11557891-Male,
pubmed-meshheading:11557891-Mice,
pubmed-meshheading:11557891-Mice, Knockout,
pubmed-meshheading:11557891-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:11557891-Organ Size,
pubmed-meshheading:11557891-Organ Specificity,
pubmed-meshheading:11557891-Ovarian Follicle,
pubmed-meshheading:11557891-Ovary,
pubmed-meshheading:11557891-Ovulation,
pubmed-meshheading:11557891-Protein Subunits,
pubmed-meshheading:11557891-Signal Transduction,
pubmed-meshheading:11557891-TATA-Binding Protein Associated Factors,
pubmed-meshheading:11557891-Transcription, Genetic,
pubmed-meshheading:11557891-Transcription Factor TFIID,
pubmed-meshheading:11557891-Transcription Factors,
pubmed-meshheading:11557891-Transcription Factors, TFII
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pubmed:year |
2001
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pubmed:articleTitle |
Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development.
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pubmed:affiliation |
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720-3204, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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