Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-9-13
pubmed:abstractText
Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by dryness of the eyes and mouth. Currently, the highly polymorphic major histocompatibility complex (MHC) genes are the best documented genetic risk factor for the development of autoimmune disease. We examined the MHC class II alleles DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1 in a group of Norwegian pSS patients and compared with a group of healthy controls. Because a number of studies have shown that some of the MHC class II alleles are not associated with the disease as a whole, but rather to the development of autoantibodies, anti-Ro52 autoantibodies in serum were measured and compared to MHC class II allele status. A clear association with pSS was detected for the DRB1*0301 and DRB3*0101 alleles, but these alleles were more closely associated with the presence of anti-Ro52 autoantibodies than with pSS itself. Moreover, the DQA1*0501 and DQB1*0201 alleles were only associated with the presence of anti-Ro52 autoantibodies. This study shows that the production of anti-Ro52 autoantibodies in pSS is associated with the DRB1*0301, DRB3*0101, DQA1*0501 and DQB1*0201 alleles which are in strong linkage disequilibrium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies, http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ alpha-Chains, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ beta-Chains, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQA1 antigen, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQB1 antigen, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1*03:01 antigen, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1 Chains, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB3 Chains, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB4 Chains, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB5 Chains, http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Isotypes, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Cytoplasmic, http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins, http://linkedlifedata.com/resource/pubmed/chemical/SS-A antigen, http://linkedlifedata.com/resource/pubmed/chemical/SS-B antigen, http://linkedlifedata.com/resource/pubmed/chemical/TROVE2 protein, human
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
428-33
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11555411-Alleles, pubmed-meshheading:11555411-Autoantibodies, pubmed-meshheading:11555411-Autoantigens, pubmed-meshheading:11555411-Female, pubmed-meshheading:11555411-HLA-DQ Antigens, pubmed-meshheading:11555411-HLA-DQ alpha-Chains, pubmed-meshheading:11555411-HLA-DQ beta-Chains, pubmed-meshheading:11555411-HLA-DR Antigens, pubmed-meshheading:11555411-HLA-DRB1 Chains, pubmed-meshheading:11555411-HLA-DRB3 Chains, pubmed-meshheading:11555411-HLA-DRB4 Chains, pubmed-meshheading:11555411-HLA-DRB5 Chains, pubmed-meshheading:11555411-Histocompatibility Antigens Class II, pubmed-meshheading:11555411-Humans, pubmed-meshheading:11555411-Immunoglobulin A, pubmed-meshheading:11555411-Immunoglobulin G, pubmed-meshheading:11555411-Immunoglobulin Isotypes, pubmed-meshheading:11555411-Immunoglobulin M, pubmed-meshheading:11555411-Male, pubmed-meshheading:11555411-Norway, pubmed-meshheading:11555411-RNA, Small Cytoplasmic, pubmed-meshheading:11555411-Ribonucleoproteins, pubmed-meshheading:11555411-Sjogren's Syndrome
pubmed:year
2001
pubmed:articleTitle
Associations of MHC class II alleles in Norwegian primary Sjögren's syndrome patients: implications for development of autoantibodies to the Ro52 autoantigen.
pubmed:affiliation
Broegelmann Research Laboratory, University of Bergen, Norway. Britt.Nakken@gades.uib.no
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't