Linked Life Data

11549751

Source:http://linkedlifedata.com/resource/pubmed/id/11549751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2001-9-10
pubmed:abstractText
Current propositions of the quantity of sound driving the central auditory system, specifically around threshold, are diverse and at variance with one another. They include sound pressure, sound power, or intensity, which are proportional to the square of pressure, and energy, i.e., the integral of sound power over time. Here we show that the relevant sound quantity and the nature of the threshold can be obtained from the timing of the first spike of auditory-nerve (AN) fibers after the onset of a stimulus. We reason that the first spike is triggered when the stimulus reaches threshold and occurs with fixed delay thereafter. By probing cat AN fibers with characteristic frequency tones of different sound pressure levels and rise times, we show that the differences in relative timing of the first spike (including latencies >100 msec of fibers with low spontaneous rates) can be well accounted for by essentially linear integration of pressure over time. The inclusion of a constant pressure loss or gain to the integrator improves the fit of the model and also accounts for most of the variation of spontaneous rates across fibers. In addition, there are tight correlations among delay, threshold, and spontaneous rate. First-spike timing cannot be explained by models based on a fixed pressure threshold, a fixed power or intensity threshold, or an energy threshold. This suggests that AN fiber thresholds are best measured in units of pressure by time. Possible mechanisms of pressure integration by the inner hair cell-AN fiber complex are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7404-15
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Temporal integration of sound pressure determines thresholds of auditory-nerve fibers.
pubmed:affiliation
Leibniz Institute for Neurobiology, D-39118 Magdeburg, Germany. peter.heil@ifn-magdeburg.de
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't