Linked Life Data

11542790

Source:http://linkedlifedata.com/resource/pubmed/id/11542790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-4-8
pubmed:abstractText
Astronauts are exposed to heavy ions during space missions and heavy ion induced-chromosome damages have been observed in their lymphocytes. This raises the problem of the consequence of longer space flights. Recent studies show that some alterations can appear many cell generations after the initial radiation exposure as a delayed genomic instability. This delayed instability is characterized by the accumulation of cell alterations leading to cell transformation, delayed cell death and mutations. Chromosome instability was shown in vitro in different model systems (Sabatier et al., 1992; Marder and Morgan, 1993, Kadhim et al., 1994 and Holmberg et al., 1993, 1995). All types of radiation used induce a chromosome instability, however, heavy ions cause the most damage. The period of chromosome instability followed by the formation of clones with unbalanced karyotypes seems to be shared by cancer cells. The shortening of telomere sequences leading to the formation of telomere fusions is an important factor in the appearance of this chromosome instability.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
S
pubmed:status
MEDLINE
pubmed:issn
0273-1177
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NASA
pubmed:authorsComplete
Y
pubmed:pagination
597-602
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Role of chromosome instability in long term effect of manned-space missions.
pubmed:affiliation
Commissariat a l'Energie Atomique, DSV/DRR/Laboratory of Radiobiology and Oncology, Fontenay-aux-Roses, France.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't