Linked Life Data

11542415

Source:http://linkedlifedata.com/resource/pubmed/id/11542415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1999-11-28
pubmed:abstractText
We analyzed DNA and proteins obtained from normal and transformed human mammary epithelial cells for studying the neoplastic transformation by high-LET irradiation in vitro. We also examined microsatellite instability in human mammary cells transformed to various stages of carcinogenesis, such as normal, growth variant and tumorigenic, using microsatellite marker D5S177 on the chromosome 5 and CYl7 on the Chromosome 10. Microsatellite instabilities were detected in the tumorigenic stage. These results suggest that microsatellite instability may play a role in the progression of tumorigenecity. The cause of the genomic instability has been suggested as abnormalities of DNA-repair systems which may be due to one of the three reasons: 1) alterations of cell cycle regulating genes. 2) mutations in any of the DNA mismatch repair genes, 3) mutation in any of the DNA strand breaks repair genes. No abnormality of these genes and encoded proteins, however was found in the present studies. These studies thus suggest that the microsatellite instability is induced by an alternative mechanism.
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
S
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0273-1177
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NASA
pubmed:authorsComplete
Y
pubmed:pagination
1709-17
pubmed:dateRevised
2007-4-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Microsatellite instability in human mammary epithelial cells transformed by heavy ions.
pubmed:affiliation
Research Center of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.
pubmed:publicationType
Journal Article