|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2001-9-5
|
|
pubmed:abstractText |
186Re-labeled chimeric monoclonal antibody U36 (cMAb U36) was recently evaluated in a phase I dose escalation study in head and neck cancer patients. All 13 patients received 99mTc-labeled cMAb U36 before 186Re-cMAb U36 radioimmunotherapy. The aim of this study was to evaluate the suitability of multiple or limited blood sampling to predict clearance, red marrow absorbed dose, and myelotoxicity of 186Re-cMAb U36.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0161-5505
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
42
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1364-7
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11535726-Aged,
pubmed-meshheading:11535726-Algorithms,
pubmed-meshheading:11535726-Antibodies, Monoclonal,
pubmed-meshheading:11535726-Area Under Curve,
pubmed-meshheading:11535726-Bayes Theorem,
pubmed-meshheading:11535726-Bone Marrow,
pubmed-meshheading:11535726-Female,
pubmed-meshheading:11535726-Head and Neck Neoplasms,
pubmed-meshheading:11535726-Humans,
pubmed-meshheading:11535726-Male,
pubmed-meshheading:11535726-Middle Aged,
pubmed-meshheading:11535726-Predictive Value of Tests,
pubmed-meshheading:11535726-Radioimmunotherapy,
pubmed-meshheading:11535726-Radioisotopes,
pubmed-meshheading:11535726-Radiotherapy Dosage,
pubmed-meshheading:11535726-Recombinant Fusion Proteins,
pubmed-meshheading:11535726-Regression Analysis,
pubmed-meshheading:11535726-Rhenium,
pubmed-meshheading:11535726-Thrombocytopenia
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Evaluation of limited blood sampling in a preceding 99mTc-labeled diagnostic study to predict the pharmacokinetics and myelotoxicity of 186Re-cMAb U36 radioimmunotherapy.
|
|
pubmed:affiliation |
Department of Otolaryngology/Head and Neck Surgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
|
