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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-9-5
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pubmed:abstractText |
Mutations in the cardiac sodium (Na) channel gene (SCN5A) give rise to the congenital long-QT syndrome (LQT3) and the Brugada syndrome. Na channel blockade by antiarrhythmic drugs improves the QT interval prolongation in LQT3 but worsens the Brugada syndrome ST-segment elevation. Although Na channel blockade has been proposed as a treatment for LQT3, flecainide also evokes "Brugada-like" ST-segment elevation in LQT3 patients. Here, we examine how Na channel inactivation gating defects in LQT3 and Brugada syndrome elicit proarrhythmic sensitivity to flecainide.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1200-5
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:11535580-Anti-Arrhythmia Agents,
pubmed-meshheading:11535580-Arrhythmias, Cardiac,
pubmed-meshheading:11535580-Cell Line,
pubmed-meshheading:11535580-Electrocardiography,
pubmed-meshheading:11535580-Flecainide,
pubmed-meshheading:11535580-Green Fluorescent Proteins,
pubmed-meshheading:11535580-Humans,
pubmed-meshheading:11535580-Ion Channel Gating,
pubmed-meshheading:11535580-Long QT Syndrome,
pubmed-meshheading:11535580-Luminescent Proteins,
pubmed-meshheading:11535580-Membrane Potentials,
pubmed-meshheading:11535580-Mutation,
pubmed-meshheading:11535580-Patch-Clamp Techniques,
pubmed-meshheading:11535580-Recombinant Fusion Proteins,
pubmed-meshheading:11535580-Sodium Channels,
pubmed-meshheading:11535580-Syndrome,
pubmed-meshheading:11535580-Transfection
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pubmed:year |
2001
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pubmed:articleTitle |
Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes.
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pubmed:affiliation |
Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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