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rdf:type |
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lifeskim:mentions |
umls-concept:C0009325,
umls-concept:C0013081,
umls-concept:C0018787,
umls-concept:C0086418,
umls-concept:C0181598,
umls-concept:C0183683,
umls-concept:C0301630,
umls-concept:C0344211,
umls-concept:C0623362,
umls-concept:C1171411,
umls-concept:C1317973,
umls-concept:C1521721,
umls-concept:C1883709
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|
pubmed:issue |
10
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|
pubmed:dateCreated |
2001-9-5
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|
pubmed:abstractText |
Left ventricular assist device (LVAD) support of the failing heart induces salutary changes in myocardial structure and function. Matrix metalloproteinases (MMPs) are increased in the failing heart and are induced by stretch in cardiac cells in vitro. We hypothesized that mechanical unloading may affect LV plasticity by regulating MMPs and their substrates.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
|
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pubmed:issn |
1524-4539
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
4
|
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1147-52
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11535571-Adult,
pubmed-meshheading:11535571-Blotting, Western,
pubmed-meshheading:11535571-Collagen,
pubmed-meshheading:11535571-Down-Regulation,
pubmed-meshheading:11535571-Enzyme Precursors,
pubmed-meshheading:11535571-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:11535571-Heart Failure,
pubmed-meshheading:11535571-Heart-Assist Devices,
pubmed-meshheading:11535571-Humans,
pubmed-meshheading:11535571-Immunohistochemistry,
pubmed-meshheading:11535571-Matrix Metalloproteinase 9,
pubmed-meshheading:11535571-Matrix Metalloproteinases,
pubmed-meshheading:11535571-Middle Aged,
pubmed-meshheading:11535571-Myocardium,
pubmed-meshheading:11535571-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:11535571-Tissue Inhibitor of Metalloproteinase-2,
pubmed-meshheading:11535571-Tissue Inhibitor of Metalloproteinase-3,
pubmed-meshheading:11535571-Tissue Inhibitor of Metalloproteinases,
pubmed-meshheading:11535571-Ventricular Dysfunction, Left
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pubmed:year |
2001
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pubmed:articleTitle |
Downregulation of matrix metalloproteinases and reduction in collagen damage in the failing human heart after support with left ventricular assist devices.
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pubmed:affiliation |
Cardiovascular Institute, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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