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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-9-5
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pubmed:abstractText |
In healthy humans, continuous treatment with nitroglycerin (GTN) causes nitric oxide synthase dysfunction, probably through the reduced bioavailability of tetrahydrobiopterin. Recent studies proposed that folic acid is involved in the regeneration of tetrahydrobiopterin in different disease states. Therefore, we investigated whether folic acid administration would prevent this phenomenon. We also sought to determine if folic acid supplementation could prevent the development of tolerance to GTN.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1119-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11535566-Acetylcholine,
pubmed-meshheading:11535566-Adult,
pubmed-meshheading:11535566-Blood Flow Velocity,
pubmed-meshheading:11535566-Blood Pressure,
pubmed-meshheading:11535566-Dose-Response Relationship, Drug,
pubmed-meshheading:11535566-Double-Blind Method,
pubmed-meshheading:11535566-Drug Tolerance,
pubmed-meshheading:11535566-Enzyme Inhibitors,
pubmed-meshheading:11535566-Folic Acid,
pubmed-meshheading:11535566-Forearm,
pubmed-meshheading:11535566-Heart Rate,
pubmed-meshheading:11535566-Hematinics,
pubmed-meshheading:11535566-Homocysteine,
pubmed-meshheading:11535566-Humans,
pubmed-meshheading:11535566-Infusion Pumps,
pubmed-meshheading:11535566-Male,
pubmed-meshheading:11535566-Nitric Oxide Synthase,
pubmed-meshheading:11535566-Nitroglycerin,
pubmed-meshheading:11535566-Vasodilator Agents,
pubmed-meshheading:11535566-omega-N-Methylarginine
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pubmed:year |
2001
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pubmed:articleTitle |
Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo study.
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pubmed:affiliation |
Division of Cardiology, Department of Medicine, Mount Sinai Hospital, and the University of Toronto, Toronto, Canada.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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