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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-8-29
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pubmed:databankReference |
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pubmed:abstractText |
Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B and other signaling pathways through the adapter protein MyD88. Although some cellular responses are completely abolished in MyD88-deficient mice, TLR4, but not TLR9, can activate NF-kappa B and mitogen-activated protein kinases and induce dendritic cell maturation in the absence of MyD88. These differences suggest that another adapter must exist that can mediate MyD88-independent signaling in response to TLR4 ligation. We have identified and characterized a Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) and have shown that it controls activation of MyD88-independent signaling pathways downstream of TLR4. We have also shown that the double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/DNAJC3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HSP40 Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/MYD88 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myd88 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TLR9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 9,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/eIF-2 Kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
835-41
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11526399-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11526399-Amino Acid Sequence,
pubmed-meshheading:11526399-Animals,
pubmed-meshheading:11526399-Antigens, Differentiation,
pubmed-meshheading:11526399-Cell Differentiation,
pubmed-meshheading:11526399-Cell Line,
pubmed-meshheading:11526399-Cloning, Molecular,
pubmed-meshheading:11526399-CpG Islands,
pubmed-meshheading:11526399-Dendritic Cells,
pubmed-meshheading:11526399-Drosophila Proteins,
pubmed-meshheading:11526399-HSP40 Heat-Shock Proteins,
pubmed-meshheading:11526399-Humans,
pubmed-meshheading:11526399-Lipopolysaccharides,
pubmed-meshheading:11526399-Membrane Glycoproteins,
pubmed-meshheading:11526399-Mice,
pubmed-meshheading:11526399-Molecular Sequence Data,
pubmed-meshheading:11526399-Mutation,
pubmed-meshheading:11526399-Myeloid Differentiation Factor 88,
pubmed-meshheading:11526399-Receptors, Cell Surface,
pubmed-meshheading:11526399-Receptors, Immunologic,
pubmed-meshheading:11526399-Receptors, Interleukin-1,
pubmed-meshheading:11526399-Sequence Homology, Amino Acid,
pubmed-meshheading:11526399-Signal Transduction,
pubmed-meshheading:11526399-Toll-Like Receptor 4,
pubmed-meshheading:11526399-Toll-Like Receptor 9,
pubmed-meshheading:11526399-Toll-Like Receptors,
pubmed-meshheading:11526399-eIF-2 Kinase
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pubmed:year |
2001
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pubmed:articleTitle |
TIRAP: an adapter molecule in the Toll signaling pathway.
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pubmed:affiliation |
Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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