Source:http://linkedlifedata.com/resource/pubmed/id/11520728
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-8-24
|
| pubmed:abstractText |
After tracheal extubation, upper and total airway resistances may frequently be increased resulting in an increase in inspiratory effort to breathe. We tested whether breathing a helium-oxygen mixture (HeO(2)) would reduce inspiratory effort in the period after extubation. Eighteen consecutive patients with no chronic obstructive pulmonary disease who had received mechanical ventilation (> 48 h) were successively studied immediately after extubation (N(2)O(2)), 15 min after breathing HeO(2), and after return to N(2)O(2). Effort to breathe, assessed by the transdiaphragmatic pressure swings (DeltaPdi) and the pressure-time index of the diaphragm (PTI), comfort, and gas exchange, were the main end points. The mean reduction of the transdiaphragmatic pressure under HeO(2) was 19 +/- 5%. All but three patients presented a decrease in transdiaphragmatic pressure under HeO(2), ranging from - 4 to - 55%, and a significant reduction in DeltaPdi was observed between HeO(2) and N(2)O(2) (10.2 +/- 0.7 versus 8.6 +/- 1.1 versus 10.0 +/- 0.8 cm H(2)O for the three consecutive periods; p < 0.05). PTI also differed significantly between HeO(2) and N(2)O(2) (197 +/- 19 versus 166 +/- 22 versus 201 +/- 23 cm H(2)O/s/min for the three periods; p < 0.05). Breathing HeO(2) significantly improved comfort, whereas gas exchange was not modified. We conclude that the use of HeO(2) in the immediate postextubation period decreases inspiratory effort and improves comfort.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1073-449X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
164
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
633-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11520728-Administration, Inhalation,
pubmed-meshheading:11520728-Adolescent,
pubmed-meshheading:11520728-Adult,
pubmed-meshheading:11520728-Aged,
pubmed-meshheading:11520728-Aged, 80 and over,
pubmed-meshheading:11520728-Analysis of Variance,
pubmed-meshheading:11520728-Blood Gas Analysis,
pubmed-meshheading:11520728-Diaphragm,
pubmed-meshheading:11520728-Drug Therapy, Combination,
pubmed-meshheading:11520728-Female,
pubmed-meshheading:11520728-Helium,
pubmed-meshheading:11520728-Hemodynamics,
pubmed-meshheading:11520728-Humans,
pubmed-meshheading:11520728-Inspiratory Capacity,
pubmed-meshheading:11520728-Intubation, Intratracheal,
pubmed-meshheading:11520728-Male,
pubmed-meshheading:11520728-Middle Aged,
pubmed-meshheading:11520728-Oxygen Inhalation Therapy,
pubmed-meshheading:11520728-Pressure,
pubmed-meshheading:11520728-Pulmonary Gas Exchange,
pubmed-meshheading:11520728-Respiratory Insufficiency,
pubmed-meshheading:11520728-Time Factors,
pubmed-meshheading:11520728-Treatment Outcome,
pubmed-meshheading:11520728-Ventilator Weaning,
pubmed-meshheading:11520728-Work of Breathing
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Helium-oxygen in the postextubation period decreases inspiratory effort.
|
| pubmed:affiliation |
Service de Réanimation Médicale, Hôpital Henri Mondor, AP-HP, Université Paris, France.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|