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pubmed-article:11520139pubmed:abstractTextThe dual function of beta-catenin (e.g., as an intermediate protein between adherence junctions and the microfilaments, and as a mediator of the Wnt signaling pathway) is currently known. Stabilization of beta-catenin and subsequent activation of the Wnt signaling pathway are involved in the development of some malignancies. We analyzed the immunohistochemical localization of beta-catenin and the somatic mutation of exon 3 of the beta-catenin gene in the malignant phenotype of the uterine cervix.lld:pubmed
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pubmed-article:11520139pubmed:copyrightInfoCopyright 2001 Academic Press.lld:pubmed
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pubmed-article:11520139pubmed:dateRevised2005-11-17lld:pubmed
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pubmed-article:11520139pubmed:articleTitleCytoplasmic/nuclear expression without mutation of exon 3 of the beta-catenin gene is frequent in the development of the neoplasm of the uterine cervix.lld:pubmed
pubmed-article:11520139pubmed:affiliationDepartment of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, 500-8705, Japan.lld:pubmed
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