|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007873,
umls-concept:C0015295,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0026882,
umls-concept:C0105770,
umls-concept:C0185117,
umls-concept:C0332183,
umls-concept:C0521447,
umls-concept:C0521449,
umls-concept:C1527148,
umls-concept:C2911684
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|
pubmed:issue |
3
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|
pubmed:dateCreated |
2001-8-24
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|
pubmed:abstractText |
The dual function of beta-catenin (e.g., as an intermediate protein between adherence junctions and the microfilaments, and as a mediator of the Wnt signaling pathway) is currently known. Stabilization of beta-catenin and subsequent activation of the Wnt signaling pathway are involved in the development of some malignancies. We analyzed the immunohistochemical localization of beta-catenin and the somatic mutation of exon 3 of the beta-catenin gene in the malignant phenotype of the uterine cervix.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0090-8258
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
450-5
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:11520139-Adult,
pubmed-meshheading:11520139-Aged,
pubmed-meshheading:11520139-Carcinoma, Squamous Cell,
pubmed-meshheading:11520139-Carcinoma in Situ,
pubmed-meshheading:11520139-Cell Nucleus,
pubmed-meshheading:11520139-Cytoplasm,
pubmed-meshheading:11520139-Cytoskeletal Proteins,
pubmed-meshheading:11520139-Exons,
pubmed-meshheading:11520139-Female,
pubmed-meshheading:11520139-Humans,
pubmed-meshheading:11520139-Immunohistochemistry,
pubmed-meshheading:11520139-Middle Aged,
pubmed-meshheading:11520139-Mutation,
pubmed-meshheading:11520139-Polymerase Chain Reaction,
pubmed-meshheading:11520139-Precancerous Conditions,
pubmed-meshheading:11520139-Trans-Activators,
pubmed-meshheading:11520139-Uterine Cervical Neoplasms,
pubmed-meshheading:11520139-beta Catenin
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
Cytoplasmic/nuclear expression without mutation of exon 3 of the beta-catenin gene is frequent in the development of the neoplasm of the uterine cervix.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, 500-8705, Japan.
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pubmed:publicationType |
Journal Article
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