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rdf:type |
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lifeskim:mentions |
umls-concept:C0030685,
umls-concept:C0205378,
umls-concept:C0391871,
umls-concept:C0599682,
umls-concept:C0680255,
umls-concept:C1160421,
umls-concept:C1283071,
umls-concept:C1546857,
umls-concept:C1552933,
umls-concept:C1621749,
umls-concept:C1963578,
umls-concept:C2700485
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pubmed:issue |
17
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pubmed:dateCreated |
2001-8-22
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pubmed:abstractText |
Thalamocortical neurons innervating the barrel cortex in neonatal rodents transiently store serotonin (5-HT) in synaptic vesicles by expressing the plasma membrane serotonin transporter (5-HTT) and the vesicular monoamine transporter (VMAT2). 5-HTT knock-out (ko) mice reveal a nearly complete absence of 5-HT in the cerebral cortex by immunohistochemistry, and of barrels, both at P7 and adulthood. Quantitative electron microscopy reveals that 5-HTT ko affects neither the density of synapses nor the length of synaptic contacts in layer IV. VMAT2 ko mice, completely lacking activity-dependent vesicular release of monoamines including 5-HT, also show a complete lack of 5-HT in the cortex but display largely normal barrel fields, despite sometimes markedly reduced postnatal growth. Transient 5-HTT expression is thus required for barrel pattern formation, whereas activity-dependent vesicular 5-HT release is not.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biogenic Monoamines,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fenclonine,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Anion Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Slc18a2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Biogenic Amine Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Monoamine Transport...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1529-2401
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pubmed:author |
pubmed-author:ArellanoJJ,
pubmed-author:BaldiAA,
pubmed-author:CabibSS,
pubmed-author:ConciatoriMM,
pubmed-author:DeFelipeJJ,
pubmed-author:Gimenez-AmayaJ MJM,
pubmed-author:HallF SFS,
pubmed-author:HallS FSF,
pubmed-author:KellerFF,
pubmed-author:LeschK PKP,
pubmed-author:MarinoRR,
pubmed-author:MengualEE,
pubmed-author:MoessnerRR,
pubmed-author:MurphyD LDL,
pubmed-author:PascucciTT,
pubmed-author:PersicoA MAM,
pubmed-author:REGOS FSF,
pubmed-author:RevayR SRS,
pubmed-author:UhlG RGR
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6862-73
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pubmed:dateRevised |
2006-11-20
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pubmed:meshHeading |
pubmed-meshheading:11517274-Aging,
pubmed-meshheading:11517274-Animals,
pubmed-meshheading:11517274-Biogenic Monoamines,
pubmed-meshheading:11517274-Carrier Proteins,
pubmed-meshheading:11517274-Extracellular Space,
pubmed-meshheading:11517274-Fenclonine,
pubmed-meshheading:11517274-GABA Plasma Membrane Transport Proteins,
pubmed-meshheading:11517274-Immunohistochemistry,
pubmed-meshheading:11517274-Membrane Glycoproteins,
pubmed-meshheading:11517274-Membrane Proteins,
pubmed-meshheading:11517274-Membrane Transport Proteins,
pubmed-meshheading:11517274-Mice,
pubmed-meshheading:11517274-Mice, Inbred C57BL,
pubmed-meshheading:11517274-Mice, Knockout,
pubmed-meshheading:11517274-Nerve Tissue Proteins,
pubmed-meshheading:11517274-Neurons, Afferent,
pubmed-meshheading:11517274-Neuropeptides,
pubmed-meshheading:11517274-Organic Anion Transporters,
pubmed-meshheading:11517274-Serotonin,
pubmed-meshheading:11517274-Serotonin Antagonists,
pubmed-meshheading:11517274-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:11517274-Somatosensory Cortex,
pubmed-meshheading:11517274-Synapses,
pubmed-meshheading:11517274-Synaptic Vesicles,
pubmed-meshheading:11517274-Thalamus,
pubmed-meshheading:11517274-Vesicular Biogenic Amine Transport Proteins,
pubmed-meshheading:11517274-Vesicular Monoamine Transport Proteins,
pubmed-meshheading:11517274-Vibrissae
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pubmed:year |
2001
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pubmed:articleTitle |
Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release.
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pubmed:affiliation |
Laboratory of Neuroscience, Università "Campus Bio-Medico," 00155 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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