Linked Life Data

11516565

Source:http://linkedlifedata.com/resource/pubmed/id/11516565

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-8-22
pubmed:abstractText
Brain-derived neurotrophic factor (BDNF) is implicated in the control of hippocampal development. In this study, we have analyzed the developmental expression of BDNF mRNA/protein and its receptor tyrosine protein kinase receptor (trk) B mRNA in the mouse hippocampus by competitive reverse transcription/polymerase chain reaction and enzyme-linked immunoassay. Cell-type specificity of BDNF/trkB expression was studied in primary hippocampal cultures. BDNF levels increased stepwise from embryonic day 15 until the second postnatal week, whereas trkB expression was stable throughout development. Neurons and astrocytes expressed both BDNF and trkB. Our data suggest that developmental BDNF action mainly occurs postnatally and indicates that hippocampal neurons and astroglia not only produce BDNF but also appear to be targets for BDNF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
307
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-4
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Pre- and postnatal expression of brain-derived neurotrophic factor mRNA/protein and tyrosine protein kinase receptor B mRNA in the mouse hippocampus.
pubmed:affiliation
Abteilung Anatomie und Zellbiologie, Universität Ulm, D-89069 Ulm, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't