Source:http://linkedlifedata.com/resource/pubmed/id/11516407
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-8-22
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| pubmed:abstractText |
We report that rats learning a spatial memory task in the Morris water maze show elevated expression of the signal transduction receptor for BDNF and the synaptic associated protein synapsin I in the hippocampus. Nuclease protection assays showed maximal levels of TrkB and synapsin I mRNAs in the hippocampus by the time that asymptotic learning performance had been reached (Day 6). Increases in synapsin I mRNA were matched by changes in synapsin I protein as revealed by western blot analysis. Synapsin I is a downstream effector for the BDNF tyrosine kinase cascade pathway which has important roles in synaptic remodeling and function. Therefore, parallel changes in TrkB and synapsin I mRNAs suggest a role of the BDNF system in synaptic function or adaptation. Levels of TrkB mRNA in the hippocampus were attenuated after learning acquisition (Day 20), but synapsin I mRNA was still elevated, suggesting that the BDNF system may participate in events secondary to learning, such as strengthening of neural circuits. TrkB and synapsin I mRNAs showed an increasing trend in the cerebellum of learning rats and no changes were observed in the caudal cerebral cortex. The selectivity of the changes in trkB and synapsin I, affecting the hippocampus, is in agreement with the role of this structure in processing of spatial information. Behavioral regulation of neurotrophins may provide a molecular basis for the enhanced cognitive function associated with active lifestyles, and guide development of strategies to promote neural healing after CNS injury or disease.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0006-8993
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
904
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
13-9
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:11516407-Animals,
pubmed-meshheading:11516407-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:11516407-Cerebellum,
pubmed-meshheading:11516407-Gene Expression Regulation,
pubmed-meshheading:11516407-Hippocampus,
pubmed-meshheading:11516407-Male,
pubmed-meshheading:11516407-Maze Learning,
pubmed-meshheading:11516407-Memory,
pubmed-meshheading:11516407-Neuronal Plasticity,
pubmed-meshheading:11516407-Neurons,
pubmed-meshheading:11516407-Psychomotor Performance,
pubmed-meshheading:11516407-RNA, Messenger,
pubmed-meshheading:11516407-Rats,
pubmed-meshheading:11516407-Rats, Sprague-Dawley,
pubmed-meshheading:11516407-Receptor, trkB,
pubmed-meshheading:11516407-Space Perception,
pubmed-meshheading:11516407-Synapsins,
pubmed-meshheading:11516407-Up-Regulation
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| pubmed:year |
2001
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| pubmed:articleTitle |
Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus.
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| pubmed:affiliation |
Department of Physiological Science, UCLA, Los Angeles, CA 90095-1527, USA. fgomezpi@physci.ucla.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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