It has previously been demonstrated that 17-allylamino geldanamycin (17-AAG) enhances paclitaxel-mediated cytotoxicity and downregulates vascular endothelial factor expression in non-small cell lung cancer. This project was designed to evaluate the tumoricidal and antiangiogeneic effects of 17-AAG and paclitaxel in H358 non-small cell lung cancer cells grown as xenografts in nude mice.
Section of Thoracic Oncology and Surgical Metabolism, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Dao_Nguyen@nih.gov