| pubmed-article:11514551 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11514551 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:11514551 | lifeskim:mentions | umls-concept:C0035295 | lld:lifeskim |
| pubmed-article:11514551 | lifeskim:mentions | umls-concept:C1442488 | lld:lifeskim |
| pubmed-article:11514551 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:11514551 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:11514551 | lifeskim:mentions | umls-concept:C1698986 | lld:lifeskim |
| pubmed-article:11514551 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:11514551 | pubmed:dateCreated | 2001-10-15 | lld:pubmed |
| pubmed-article:11514551 | pubmed:abstractText | Cytosolic Ca(2+) oscillations can be due to cycles of release and re-uptake of internally stored Ca(2+). To investigate the nature of these Ca(2+) stores, we expressed the Pmr1 Ca(2+) pump of Caenorhabditis elegans in COS-1 cells and pretreated the cells with thapsigargin to prevent Ca(2+) uptake by the sarco(endo)plasmic reticulum Ca(2+)-ATPase. Pmr1 co-localized with the Golgi-specific 58K protein and was targeted to a Ca(2+) store that was less leaky for Ca(2+) than the endoplasmic reticulum and whose inositol trisphosphate receptors were less sensitive to inositol trisphosphate and ATP than those in the endoplasmic reticulum. ATP-stimulated Pmr1-overexpressing cells responded after a latency to extracellular Ca(2+) with a regenerative Ca(2+) signal, which could be prevented by caffeine. They also produced very stable ilimaquinone-sensitive baseline Ca(2+) spikes, even in the presence of thapsigargin. Such responses never occurred in non-transfected cells or in cells that overexpressed the type-1 sarco(endo)plasmic reticulum Ca(2+)-ATPase. Abortive Ca(2+) spikes also occurred in histamine-stimulated untransfected HeLa cells pretreated with thapsigargin, and they too were inhibited by ilimaquinone. We conclude that the Pmr1-induced Ca(2+) store, which probably corresponds to the Golgi compartment, can play a crucial role in setting up baseline Ca(2+) spiking. | lld:pubmed |
| pubmed-article:11514551 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11514551 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11514551 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11514551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11514551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11514551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11514551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11514551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11514551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11514551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11514551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11514551 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11514551 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11514551 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:WuytackFF | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:De SmedtHH | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:RaeymaekersLL | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:Van AckerKK | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:WeidemaA FAF | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:MissiaenLL | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:RizzutoRR | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:CallewaertGG | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:ParysJ BJB | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:RendersJJ | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:Van BaelenKK | lld:pubmed |
| pubmed-article:11514551 | pubmed:author | pubmed-author:VanoevelenJJ | lld:pubmed |
| pubmed-article:11514551 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11514551 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:11514551 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11514551 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11514551 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11514551 | pubmed:pagination | 39161-70 | lld:pubmed |
| pubmed-article:11514551 | pubmed:dateRevised | 2007-7-18 | lld:pubmed |
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| pubmed-article:11514551 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11514551 | pubmed:articleTitle | Baseline cytosolic Ca2+ oscillations derived from a non-endoplasmic reticulum Ca2+ store. | lld:pubmed |
| pubmed-article:11514551 | pubmed:affiliation | Laboratorium voor Fysiologie, K.U. Leuven Campus Gasthuisberg O/N, Herestraat 49, Leuven B-3000, Belgium. Ludwig.Missiaen@med.kuleuven.ac.be | lld:pubmed |
| pubmed-article:11514551 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11514551 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11514551 | lld:pubmed |
