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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2001-8-21
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pubmed:abstractText |
The 17-methoxy group of geldanamycin was substituted with 1,3-diaminopropane and 1,3-diamino-2-hydroxypropane to introduce a primary amino group useful for conjugation with targeting moieties and drug carriers. We have developed a procedure that has provided improved yield and reproducibility of the syntheses. Both geldanamycin derivatives demonstrated antiproliferative activity towards the human ovarian carcinoma cell line, A2780.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2089-91
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11514145-Antibiotics, Antineoplastic,
pubmed-meshheading:11514145-Benzoquinones,
pubmed-meshheading:11514145-Diamines,
pubmed-meshheading:11514145-Drug Carriers,
pubmed-meshheading:11514145-Drug Delivery Systems,
pubmed-meshheading:11514145-Drug Screening Assays, Antitumor,
pubmed-meshheading:11514145-Humans,
pubmed-meshheading:11514145-Lactams, Macrocyclic,
pubmed-meshheading:11514145-Quinones,
pubmed-meshheading:11514145-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems.
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pubmed:affiliation |
Department of Pharmaceutics and Pharmaceutical Chemistry/CCCD, University of Utah, Salt Lake City, UT 84112, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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