Linked Life Data

11513998

Source:http://linkedlifedata.com/resource/pubmed/id/11513998

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2001-8-21
pubmed:abstractText
Lichens are symbiotic associations between fungi, green algae and/or cyanobacteria. They have a varied chemistry and produce many polyketide-derived compounds, including some, such as depsides and depsidones, that are rarely reported elsewhere. Although lichens have been appreciated in traditional medicines, their value has largely been ignored by the modern pharmaceutical industry because difficulties in establishing axenic cultures and conditions for rapid growth preclude their routine use in most conventional screening processes. Recently, molecular genetic techniques using PCR, genomic library construction and heterologous expression have provided an alternative approach to begin exploring the diversity of polyketide biosynthetic pathways in lichens. The techniques can be expanded to cover other pathway types and be integrated with conventional culture collection-based screening to provide a comprehensive search for novel chemical entities in these organisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0167-7799
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
349-55
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Genetic approaches to harvesting lichen products.
pubmed:affiliation
Cubist Pharmaceuticals, 2386 East Mall, UBC, Suite 300, Vancouver, BC, Canada V6T 1Z3. vmiao@lobaria.terragen.com
pubmed:publicationType
Journal Article, Review