Linked Life Data

11505839

Source:http://linkedlifedata.com/resource/pubmed/id/11505839

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2001-8-16
pubmed:abstractText
HIGH INCIDENCE: Because of the high incidence of hepatocellular carcinoma (HCC) in patients with cirrhosis (3 to 5% per year) and the fact that curative treatment is currently available only for small sized tumors careful screening is warranted in this high risk population. Earlier screening attempts produced disappointing results in terms of cure and survival, particularly in Europe. Progress in ultrasonography, a better understanding of the risk of developing HCC, and most importantly the advent of local percutaneous treatments have greatly affected the data which should be reexamined. SCREENING METHODS: Patients with cirrhosis, particularly alcoholic or viral cirrhosis, should undergo regular ultrasound examinations, every six months for most screening protocols although the best timing remains unknown. Assay of serum alpha-fetoprotein is of limited use due to its low sensitivity and specificity. Diagnosis of HCC is basically based on helicoidal computed tomography and/or magnetic resonance imaging findings, with or without pathological proof (ultrasound-guided biopsy) that may be difficult to obtain. A probabilistic diagnosis is therefore retained if necessary, based on the presence of risk factors and arterial hypervascularization of a liver nodule. EARLY TREATMENT: With ultrasound screening, the diagnosis of HCC can generally be established early, when curative transplantation, resection or local percutaneous destruction are still feasible. The percutaneous methods use chemical or physical agents to destroy the tumor. There are few contraindications so curative treatment can be proposed for large number of patients. Large-scale prospective studies will be completed in the upcoming years and are expected to provide evidence validating the principle of screening and early treatment.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0755-4982
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1164-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Alcoholic liver cirrhosis. Screening for hepatocellular carcinoma in liver cirrhosis].
pubmed:affiliation
Service d'Hépato-Gastroentérologie, Hôpital Jean Verdier, Bondy. jean-claude.trinchet@jvr.ap-hop-paris.fr
pubmed:publicationType
Journal Article, English Abstract