Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1975-11-8
|
| pubmed:abstractText |
As previously shown, sera from tumor-bearing mice can induce specific antiserum-dependent lymphoid cell-mediated cytotoxicity (ADC) to syngeneic tumor cells in vitro. The ADC activity in such sera is now shown to be removed by adsorption of the sera to Sepharose-linked rabbit anti-mouse immunoglobulin or to goat anti-mouse IgG2. Immunoglobulins recovered by elution from the affinity columns mediated ADC to the specific tumor cells. In addition, the eluted immunoglobulin passively "armed" normal lymph-node cells in vivo so they were specifically cytotoxic when tested in vitro. Sera taken 48 h after inoculation of tumor or syngeneic tumor cells (before the appearance of palpable tumor) were also shown previously to induce lymphoid cell-mediated cytotoxicity in vitro. This cytotoxic activity was not removed by adsorption of the sera to either anti-IgG or anti-IgM-linked Sepharose. Thus both IgG and an early-appearing serum component which is apparently neither IgG nor IgM can induce specific cell-mediated cytotoxicity by non-immune lymphoid cells in vitro.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
339-46
|
| pubmed:dateRevised |
2007-7-24
|
| pubmed:meshHeading |
pubmed-meshheading:1150357-Animals,
pubmed-meshheading:1150357-Antigen-Antibody Reactions,
pubmed-meshheading:1150357-Cell Line,
pubmed-meshheading:1150357-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:1150357-Female,
pubmed-meshheading:1150357-Immune Sera,
pubmed-meshheading:1150357-Immunity, Cellular,
pubmed-meshheading:1150357-Immunoglobulin G,
pubmed-meshheading:1150357-Immunoglobulin M,
pubmed-meshheading:1150357-Lymph Nodes,
pubmed-meshheading:1150357-Lymphocytes,
pubmed-meshheading:1150357-Methylcholanthrene,
pubmed-meshheading:1150357-Mice,
pubmed-meshheading:1150357-Mice, Inbred BALB C,
pubmed-meshheading:1150357-Moloney murine leukemia virus,
pubmed-meshheading:1150357-Neoplasm Transplantation,
pubmed-meshheading:1150357-Sarcoma, Experimental,
pubmed-meshheading:1150357-Transplantation, Isogeneic
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
Evidence for two factors in sera of tumor-immunized mice which induce specific lymphoid cell-dependent cytotoxicity: IgG2 and a rapidly appearing factor not associated with IgG or IgM.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|