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rdf:type |
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lifeskim:mentions |
umls-concept:C0014323,
umls-concept:C0023206,
umls-concept:C0079429,
umls-concept:C0205103,
umls-concept:C0332256,
umls-concept:C0439064,
umls-concept:C0560013,
umls-concept:C0680022,
umls-concept:C1514562,
umls-concept:C1517488,
umls-concept:C1519249,
umls-concept:C1711351
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pubmed:issue |
9
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pubmed:dateCreated |
2001-8-13
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pubmed:databankReference |
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pubmed:abstractText |
Killing by Entamoeba histolytica requires parasite adherence to host galactose- and N-acetyl-D-galactosamine (Gal/GalNAc)-containing cell surface receptors. A 260-kDa heterodimeric E. histolytica Gal/GalNAc lectin composed of heavy (Hgl) and light (Lgl) subunits has been previously described. Here we present the cloning and characterization of Igl, a 150-kDa intermediate subunit of the Gal/GalNAc lectin. Igl, Hgl, and Lgl colocalized on the surface membrane of trophozoites. Two unlinked copies of genes encoding Igl shared 81% amino acid sequence identity (GenBank accession no. AF337950 and AF337951). They encoded cysteine-rich proteins with amino- and carboxy-terminal hydrophobic signal sequences characteristic of glycosylphosphatidylinositol (GPI)-anchored membrane proteins. The igl genes lacked carbohydrate recognition domains but were members of a large family of amebic genes containing CXXC and CXC motifs. These data indicate that Igl is part of the parasite's multimolecular Gal/GalNAc adhesin required for host interaction.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-10417146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-10802329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-10834936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-11023406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-11206109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-11207613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-1372977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-1396552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-1587790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-1881907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-1937828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-1987067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-2000392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-2352929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-2535835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-2536731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-2543634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-2580787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-2890654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-2890655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-2896759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-3335828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-6249882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-6271810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-6303959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-7476421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-7591055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-7663127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-7682994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-7836354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-7957763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-8039871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-8264736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-8821939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-9178467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-9197389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-9254694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-9284127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-9693367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-9714198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-9747935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11500468-9878032
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
pubmed-author:ChengX JXJ,
pubmed-author:GhoshSS,
pubmed-author:GilchristC ACA,
pubmed-author:HughesM AMA,
pubmed-author:HustonC DCD,
pubmed-author:LockhartL ALA,
pubmed-author:LoftusBB,
pubmed-author:MannB JBJ,
pubmed-author:Miller-SimsVV,
pubmed-author:PetriW AWAJr,
pubmed-author:TachibanaHH
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5892-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11500468-Animals,
pubmed-meshheading:11500468-Entamoeba histolytica,
pubmed-meshheading:11500468-Cysteine,
pubmed-meshheading:11500468-Lectins,
pubmed-meshheading:11500468-Amino Acid Sequence,
pubmed-meshheading:11500468-Molecular Sequence Data,
pubmed-meshheading:11500468-Protozoan Proteins,
pubmed-meshheading:11500468-Sequence Analysis, DNA,
pubmed-meshheading:11500468-Amino Acid Motifs,
pubmed-meshheading:11500468-DNA, Protozoan,
pubmed-meshheading:11500468-Blotting, Southern
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