Linked Life Data

11498938

Source:http://linkedlifedata.com/resource/pubmed/id/11498938

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pubmed-article:11498938pubmed:dateCreated2001-8-13lld:pubmed
pubmed-article:11498938pubmed:abstractTextThe Sprague-Dawley (SD) rat bearing a heteroplasted pituitary underneath renal capsule was used to observe differential expression of prolactin (PRL), transforming growth factor alpha (TGF alpha) and transforming growth factor beta 1 (TGF beta 1) genes during the formation of pituitary prolactin-secreting tumor (prolactinoma) induced by 17 beta-estradiol (E2). Our results indicated that in both eutopic and ectopic pituitaries disconnected from hypothalamus formed simultaneously PRL-secreting tumors after the rats treated with E2 for 120 days in vivo, which was accompanied by overexpression of PRL gene (P < 0.05-0.01). The PRL mRNA level was higher in eutopic prolactinoma than that in ectopic prolactinoma (P < 0.05). Overexpression of TGF alpha and TGF beta 1 genes were also detected in eutopic prolactinoma. However, the expression of TGF alpha and TGF beta 1 genes in ectopic prolactinoma was similar to that in normal pituitary. It is suggested that TGF alpha and TGF beta 1 may be involved in prolactinoma tumorigenesis of eutopic pituitary. However, the mechanism mediating eutopic and ectopic prolactin-secreting tumor formation seems different.lld:pubmed
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pubmed-article:11498938pubmed:authorpubmed-author:SenGGlld:pubmed
pubmed-article:11498938pubmed:authorpubmed-author:ZhangRRlld:pubmed
pubmed-article:11498938pubmed:authorpubmed-author:XiJ LJLlld:pubmed
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pubmed-article:11498938pubmed:volume51lld:pubmed
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pubmed-article:11498938pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11498938pubmed:articleTitle[Expression of prolactin, TGF alpha and TGF beta 1 genes in estrogen-induced eutopic and ectopic pituitary prolactin-secreting tumors of rats].lld:pubmed
pubmed-article:11498938pubmed:affiliationDepartment of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005.lld:pubmed
pubmed-article:11498938pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11498938pubmed:publicationTypeEnglish Abstractlld:pubmed
pubmed-article:11498938pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed