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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-8-10
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pubmed:abstractText |
The expression of interleukin-1beta was examined in dorsal root ganglion (DRG) neurons from adult rats using non-radioactive in situ hybridization and immunocytochemistry. At all spinal levels, approximately 70% of the DRG neurons appeared to express IL-1beta mRNA; about 80% of these DRG neurons actually appeared to produce the IL-1beta protein at markedly varying levels. The expression of IL-1beta was found in large as well as in intermediate diameter sensory neurons but only sporadically in the population of small sensory neurons. The population of IL-1beta immunopositive sensory neurons included most of the large calretinin-positive Ia afferents, but only a few of the small substance P/CGRP positive sensory neurons. In situ hybridization staining for the detection of type 1 IL-1 receptor showed expression of this receptor by most of the sensory neurons as well as by supportive glial-like cells, presumably satellite cells. The functional significance of IL-1beta in the DRG neurons needs to be elucidated, but we speculate that IL-1beta produced by DRG neurons may be an auto/paracrine signalling molecule in sensory transmission.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Protein, Vitamin...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1 Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/calretinin
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
203-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11498255-Animals,
pubmed-meshheading:11498255-Calcitonin Gene-Related Peptide,
pubmed-meshheading:11498255-Calcium-Binding Protein, Vitamin D-Dependent,
pubmed-meshheading:11498255-Cell Size,
pubmed-meshheading:11498255-Cytoplasm,
pubmed-meshheading:11498255-Female,
pubmed-meshheading:11498255-Ganglia, Spinal,
pubmed-meshheading:11498255-Immunohistochemistry,
pubmed-meshheading:11498255-In Situ Hybridization,
pubmed-meshheading:11498255-Interleukin-1,
pubmed-meshheading:11498255-Male,
pubmed-meshheading:11498255-Microscopy, Immunoelectron,
pubmed-meshheading:11498255-Neuroglia,
pubmed-meshheading:11498255-Neurons, Afferent,
pubmed-meshheading:11498255-Polyribosomes,
pubmed-meshheading:11498255-RNA, Messenger,
pubmed-meshheading:11498255-Rats,
pubmed-meshheading:11498255-Receptors, Interleukin-1,
pubmed-meshheading:11498255-Receptors, Interleukin-1 Type I,
pubmed-meshheading:11498255-Substance P
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pubmed:year |
2001
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pubmed:articleTitle |
Expression of interleukin-1 beta in rat dorsal root ganglia.
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pubmed:affiliation |
Department of Medical Physiology, University of Groningen, A. Deusinglaan 1, Bloemsingel 10, 9713 AV KZ, Groningen, Netherlands. j.c.v.m.copray@med.rug.nl
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pubmed:publicationType |
Journal Article
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